Huang He-Chen, Chen Yan, Hu Jie, Guo Xiu-Tian, Zhou Shao-Rong, Yang Qi-Qi, Du Yu-Qing, Jin Yu, Liu Guo-Bin, Peng Yun-Hua
Shuguang Hospital Affiliated to Shanghai University of traditional Chinese medicine, Shanghai, China.
Shanghai Municipal Hospital of Traditional Chinese Medicine, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Int Wound J. 2023 Oct 11;21(2). doi: 10.1111/iwj.14389.
Aimed to clarify the effect of quercetin and its derivatives on wound healing in animal experiments. PubMed, Embase, Science Direct, Web of Science, SinoMed, Vip Journal Integration Platform, China National Knowledge Infrastructure and WanFang databases were searched for animal experiments investigating the effect of quercetin and its derivatives on wound healing to April 2023. The Review Manager 5.4 software was used to conduct meta-analysis. Eighteen studies were enrolled in this article. According to the SYRCLE's RoB tool assessment, these studies exposed relatively low methodological quality. It was shown that animals with cutaneous wound receiving quercetin had faster wound healing in wound closure (%) than the control group. Moreover, the difference in efficacy gradually emerged after third day (WMD = 7.13 [5.52, 8.74]), with a peak reached on the tenth day after wounding (WMD = 19.78 [17.82, 21.74]). Subgroup analysis revealed that quercetin for wound closure (%) was independent of the types of rats and mice, wound area and with or without diabetes. Clear conclusion was also shown regarding the external application of quercetin for wound healing (WMD = 17.77 [11.11, 24.43]). A significant reduction in the distribution of inflammatory cells occurred in the quercetin group. Quercetin could increase blood vessel density (WMD = 1.85 [0.68, -3.02]), fibroblast distribution and collagen fraction. Biochemical indicators, including IL-1β, IL-10, TNF-α, TGF-β, vascular endothelial growth factor (VEGF), hydroxyproline and alpha-smooth muscle actin (α-SMA), had the consistent results. Quercetin and its derivatives could promote the recovery of cutaneous wound in animals, through inhibiting inflammatory response and accelerating angiogenesis, proliferation of fibroblast and collagen deposition.
旨在阐明槲皮素及其衍生物在动物实验中对伤口愈合的影响。检索了PubMed、Embase、Science Direct、Web of Science、SinoMed、维普资讯中文科技期刊数据库、中国知网和万方数据库，查找截至2023年4月研究槲皮素及其衍生物对伤口愈合影响的动物实验。使用Review Manager 5.4软件进行荟萃分析。本文纳入了18项研究。根据SYRCLE的RoB工具评估，这些研究的方法学质量相对较低。结果表明，接受槲皮素治疗的皮肤伤口动物在伤口闭合率（%）方面的伤口愈合速度比对照组更快。此外，第三天后疗效差异逐渐显现（加权均数差[WMD]=7.13[5.52,8.74]），在受伤后第十天达到峰值（WMD=19.78[17.82,21.74]）。亚组分析显示，槲皮素用于伤口闭合率（%）与大鼠和小鼠的类型、伤口面积以及是否患有糖尿病无关。关于槲皮素外用促进伤口愈合也有明确结论（WMD=17.77[11.11,24.43]）。槲皮素组炎症细胞分布显著减少。槲皮素可增加血管密度（WMD=1.85[0.68,-3.02]）、成纤维细胞分布和胶原分数。包括白细胞介素-1β、白细胞介素-10、肿瘤坏死因子-α、转化生长因子-β、血管内皮生长因子（VEGF）、羟脯氨酸和α-平滑肌肌动蛋白（α-SMA）在内的生化指标结果一致。槲皮素及其衍生物可通过抑制炎症反应、加速血管生成、成纤维细胞增殖和胶原沉积来促进动物皮肤伤口的恢复。
