Environment and Geography Department, University of York, York, UK.
School of Environment, Education and Development, The University of Manchester, Manchester, UK.
Environ Toxicol Chem. 2024 Mar;43(3):575-588. doi: 10.1002/etc.5763. Epub 2023 Dec 11.
Pharmaceuticals and personal care products (PPCPs) are an indispensable component of a healthy society. However, they are well-established environmental contaminants, and many can elicit biological disruption in exposed organisms. It is now a decade since the landmark review covering the top 20 questions on PPCPs in the environment (Boxall et al., 2012). In the present study we discuss key research priorities for the next 10 years with a focus on how regions where PPCPs pose the greatest risk to environmental and human health, either now or in the future, can be identified. Specifically, we discuss why this problem is of importance and review our current understanding of PPCPs in the aquatic environment. Foci include PPCP occurrence and what drives their environmental emission as well as our ability to both quantify and model their distribution. We highlight critical areas for future research including the involvement of citizen science for environmental monitoring and using modeling techniques to bridge the gap between research capacity and needs. Because prioritization of regions in need of environmental monitoring is needed to assess future/current risks, we also propose four criteria with which this may be achieved. By applying these criteria to available monitoring data, we narrow the focus on where monitoring efforts for PPCPs are most urgent. Specifically, we highlight 19 cities across Africa, Central America, the Caribbean, and Asia as priorities for future environmental monitoring and risk characterization and define four priority research questions for the next 10 years. Environ Toxicol Chem 2024;43:575-588. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
药品和个人护理用品（PPCPs）是健康社会不可或缺的组成部分。然而，它们是公认的环境污染物，许多物质会对暴露于其中的生物产生生物干扰。自 Boxall 等人（2012 年）对环境中 PPCPs 的 20 个重点问题进行了具有里程碑意义的综述以来，已经过去了十年。在本研究中，我们讨论了未来 10 年的重点研究优先事项，重点是如何确定那些现在或将来对环境和人类健康构成最大风险的地区。具体而言，我们讨论了为什么这个问题很重要，并回顾了我们目前对水生环境中 PPCPs 的理解。重点包括 PPCP 的出现及其驱动环境排放的原因，以及我们量化和模拟其分布的能力。我们强调了未来研究的关键领域，包括公民科学在环境监测中的参与以及使用建模技术来弥合研究能力和需求之间的差距。因为需要对需要环境监测的地区进行优先排序，以评估未来/当前的风险，所以我们还提出了四个可以实现这一目标的标准。通过将这些标准应用于可用的监测数据，我们将重点缩小到 PPCP 监测最紧迫的地区。具体来说，我们确定了非洲、中美洲、加勒比地区和亚洲的 19 个城市作为未来环境监测和风险评估的优先事项，并为未来 10 年确定了四个优先研究问题。Environ Toxicol Chem 2024;43:575-588. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
