Longgang Maternity and Child Institute of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Clinical Laboratory , Shenzhen, China.
Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Clinical Laboratory , Guangzhou, Guangdong, China.
Microbiol Spectr. 2023 Dec 12;11(6):e0283923. doi: 10.1128/spectrum.02839-23. Epub 2023 Oct 11.
This study assessed the clinical and molecular epidemiology of carbapenem-resistant Enterobacteriaceae in pediatric inpatients at three hospitals in South China by means of screening stool samples for carbapenem-resistant genes and a nested case-control study to determine risk factors for carriage of carbapenem-resistant Enterobacteriaceae. Of 4,033 fecal samples screened, 158 (3.92%) were positive for CRE, including (51.27 %), (37.97%), and (6.96%). The most common carbapenemase genes harbored by gastrointestinal CRE strains were blaNDM-5, blaNDM-1, and blaIMP-4. Hematological malignancies, respiratory diseases, otolaryngological diseases, nervous system diseases, oral administration of third-generation cephalosporins, and the combined use of two or more antibiotics were independently associated with CRE colonization.
本研究通过筛查粪便样本中的碳青霉烯类耐药基因，并进行巢式病例对照研究，评估了华南地区三家医院儿科住院患者中产碳青霉烯类耐药肠杆菌科（CRE）的临床和分子流行病学情况，以确定携带碳青霉烯类耐药肠杆菌科的危险因素。在筛查的 4033 份粪便样本中，有 158 份（3.92%）呈 CRE 阳性，包括 （51.27%）、 （37.97%）和 （6.96%）。胃肠道 CRE 菌株中携带的最常见的碳青霉烯酶基因是 blaNDM-5、blaNDM-1 和 blaIMP-4。血液系统恶性肿瘤、呼吸系统疾病、耳鼻喉科疾病、神经系统疾病、口服第三代头孢菌素和联合使用两种或两种以上抗生素与 CRE 定植独立相关。
