缬氨霉素的生物合成
Biosynthesis of valanimycin.
作者信息
Yamato M, Takeuchi T, Umezawa H, Sakata N, Hayashi H, Hori M
出版信息
J Antibiot (Tokyo). 1986 Sep;39(9):1263-9. doi: 10.7164/antibiotics.39.1263.
PMID:3781925
Abstract
In the biosynthesis of valanimycin, valine is mostly incorporated into the isobutyl moiety of the antibiotic. The alpha-substituted acrylic moiety of valanimycin is derived from alanine. However, a part of alanine is metabolized into valine, thus incorporated also into the isobutyl moiety. Anaerobic conditions and some reducing agents strongly inhibit the biosynthesis.
摘要
在缬氨霉素的生物合成过程中，缬氨酸大多被整合到抗生素的异丁基部分。缬氨霉素的α-取代丙烯酸部分源自丙氨酸。然而，一部分丙氨酸会代谢为缬氨酸，因此也会被整合到异丁基部分。厌氧条件和一些还原剂会强烈抑制生物合成。
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