• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

哮喘小鼠模型中的性别差异具有时间和组织隔间依赖性。

Sex differences in a murine model of asthma are time and tissue compartment dependent.

机构信息

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.

Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, United States of America.

出版信息

PLoS One. 2023 Oct 11;18(10):e0271281. doi: 10.1371/journal.pone.0271281. eCollection 2023.

DOI:10.1371/journal.pone.0271281
PMID:37819947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10566727/
Abstract

Sexual dimorphism in lung inflammation is both time and tissue compartment dependent. Spatiotemporal variability in sex differences in a murine model of asthma must be accounted for when planning experiments to model the sex bias in allergic inflammation.

摘要

肺部炎症中的性别二态性既依赖于时间，也依赖于组织隔室。在计划模拟变应性炎症中性别偏向的实验时，必须考虑哮喘小鼠模型中性别差异的时空可变性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/e62caa021420/pone.0271281.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/efc7cb2ac8c0/pone.0271281.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/774a5cc15f3f/pone.0271281.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/b61eb269eefb/pone.0271281.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/1bc74c0a14d1/pone.0271281.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/7ae3abe9f9c5/pone.0271281.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/e62caa021420/pone.0271281.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/efc7cb2ac8c0/pone.0271281.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/774a5cc15f3f/pone.0271281.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/b61eb269eefb/pone.0271281.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/1bc74c0a14d1/pone.0271281.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/7ae3abe9f9c5/pone.0271281.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf4/10566727/e62caa021420/pone.0271281.g006.jpg

相似文献

1
Sex differences in a murine model of asthma are time and tissue compartment dependent.哮喘小鼠模型中的性别差异具有时间和组织隔间依赖性。
PLoS One. 2023 Oct 11;18(10):e0271281. doi: 10.1371/journal.pone.0271281. eCollection 2023.
2
Characterization of sex-related differences in allergen house dust mite-challenged airway inflammation, in two different strains of mice.鉴定两种不同品系的小鼠变应原屋尘螨激发气道炎症的性别差异。
Sci Rep. 2022 Dec 2;12(1):20837. doi: 10.1038/s41598-022-25327-7.
3
Sex Dimorphism of Allergen-Induced Secreted Proteins in Murine and Human Lungs.过敏原诱导的蛋白在鼠和人肺部中的性别二态性
Front Immunol. 2022 Jun 28;13:923986. doi: 10.3389/fimmu.2022.923986. eCollection 2022.
4
Murine model of allergic lung inflammation.
Methods Mol Biol. 2000;138:285-93. doi: 10.1385/1-59259-058-6:285.
5
Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization.变应原致敏时白细胞三烯介导的哮喘样表型的雌雄二态性。
Pharmacol Res. 2019 Jan;139:182-190. doi: 10.1016/j.phrs.2018.11.024. Epub 2018 Nov 20.
6
Sex differences in the influence of obesity on a murine model of allergic lung inflammation.肥胖对过敏性肺炎症小鼠模型影响的性别差异。
Clin Exp Allergy. 2020 Feb;50(2):256-266. doi: 10.1111/cea.13541. Epub 2019 Dec 6.
7
Maternal stress increases risk of allergic lung inflammation in adult mice.母体应激增加成年小鼠过敏性肺部炎症的风险。
Immunobiology. 2023 May;228(3):152395. doi: 10.1016/j.imbio.2023.152395. Epub 2023 May 18.
8
Distinct macrophage phenotypes in allergic and nonallergic lung inflammation.过敏性和非过敏性肺部炎症中不同的巨噬细胞表型
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L358-67. doi: 10.1152/ajplung.00341.2014. Epub 2014 Dec 12.
9
Sex-specific lung remodeling and inflammation changes in experimental allergic asthma.实验性变应性哮喘中性别特异性的肺重构和炎症变化。
J Appl Physiol (1985). 2010 Sep;109(3):855-63. doi: 10.1152/japplphysiol.00333.2010. Epub 2010 Jul 15.
10
Impacts of allergic airway inflammation on lung pathology in a mouse model of influenza A virus infection.变应性气道炎症对甲型流感病毒感染小鼠模型肺部病理的影响。
PLoS One. 2017 Feb 28;12(2):e0173008. doi: 10.1371/journal.pone.0173008. eCollection 2017.

引用本文的文献

1
Bronchial pyroptosis promotes Th17 inflammation in steroid-insensitive asthma mouse.支气管细胞焦亡促进激素抵抗型哮喘小鼠的Th17炎症反应。
Innate Immun. 2025 Jan-Dec;31:17534259251372592. doi: 10.1177/17534259251372592. Epub 2025 Aug 28.
2
Sex, hormones, and lung health.性别、激素与肺部健康。
Physiol Rev. 2025 Aug 6. doi: 10.1152/physrev.00026.2024.
3
Sex Differences in Lung B Cell Responses in a Murine Model of Asthma.哮喘小鼠模型中肺B细胞反应的性别差异

本文引用的文献

1
Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma model.雌激素在实验性哮喘模型中放大了与预先存在的特应性相关的 Th2 偏向。
Clin Exp Allergy. 2020 Mar;50(3):391-400. doi: 10.1111/cea.13544. Epub 2019 Dec 14.
2
Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK.雌二醇通过上调 MKP-2 和去磷酸化 ERK 抑制 fMLP 诱导的中性粒细胞迁移和超氧化物产生。
Int Immunopharmacol. 2019 Oct;75:105787. doi: 10.1016/j.intimp.2019.105787. Epub 2019 Aug 8.
3
NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner.
Int Arch Allergy Immunol. 2025 Apr 29:1-12. doi: 10.1159/000546024.
NOD 样受体蛋白 3 炎性小体以性别依赖的方式驱动术后机械性疼痛。
Pain. 2019 Aug;160(8):1794-1816. doi: 10.1097/j.pain.0000000000001555.
4
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.雌激素受体β通过 NF-κB 信号通路在上皮间质细胞中上调 CCL2，并招募巨噬细胞促进子宫内膜异位症的发病机制。
Hum Reprod. 2019 Apr 1;34(4):646-658. doi: 10.1093/humrep/dez019.
5
Role of estrogen receptors α and β in the development of allergic airway inflammation in mice: A possible involvement of interleukin 33 and eosinophils.雌激素受体α和β在小鼠过敏性气道炎症发展中的作用：白细胞介素33和嗜酸性粒细胞可能的参与
Toxicology. 2019 Jan 1;411:93-100. doi: 10.1016/j.tox.2018.11.002. Epub 2018 Nov 13.
6
Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice.雌激素通过调节 NLRP3 在小鼠中的活化改善过敏性气道炎症。
Biosci Rep. 2019 Jan 8;39(1). doi: 10.1042/BSR20181117. Print 2019 Jan 31.
7
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.睾酮可降低屋尘螨诱导的 2 型和白介素-17A 介导的气道炎症。
J Immunol. 2018 Oct 1;201(7):1843-1854. doi: 10.4049/jimmunol.1800293. Epub 2018 Aug 20.
8
Hormones, sex, and asthma.激素、性别与哮喘。
Ann Allergy Asthma Immunol. 2018 May;120(5):488-494. doi: 10.1016/j.anai.2018.01.016. Epub 2018 Feb 2.
9
Sex-based differences in CD103 dendritic cells promote female-predominant Th2 cytokine production during allergic asthma.性别差异导致 CD103 树突状细胞在变应性哮喘中促进女性优势的 Th2 细胞因子产生。
Clin Exp Allergy. 2018 Apr;48(4):379-393. doi: 10.1111/cea.13081. Epub 2018 Feb 2.
10
Animal models of asthma: utility and limitations.哮喘的动物模型：效用与局限性
J Asthma Allergy. 2017 Nov 7;10:293-301. doi: 10.2147/JAA.S121092. eCollection 2017.