Department of Ophthalmology, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
Shanghai Medical College, Fudan University, Shanghai, China.
Ophthalmol Retina. 2024 Mar;8(3):264-269. doi: 10.1016/j.oret.2023.10.002. Epub 2023 Nov 18.
To explore the characteristics of vitreoretinal lymphoma (VRL) in B-scan ultrasonography.
Single-center case-control study.
A total of 106 eyes of 56 patients with biopsy-proven VRL and 86 eyes of 59 patients with uveitis were included.
B-scan ultrasonography of the included eyes was performed. Evaluated were the ultrasonographic signs as well as a special pattern termed centrifugal condensation, which refers to the peripherally hyperreflective appearance of the vitreous haze in ultrasonography.
Posterior vitreous detachment, vitreoretinal adhesion, location of vitreous haze, thickening or occupying lesions of the retina, retinal detachment, and centrifugal condensation pattern of vitreous haze were evaluated through B-scan ultrasonography. The incidences of these signs were compared between the 2 groups; odds ratios (ORs) were calculated.
The incidence of vitreoretinal adhesion in patients with VRL (6/106) was lower than in patients with uveitis (20/86; P = 0.001; OR: 0.195; 95% confidence interval [CI]: 0.073-0.522). The incidence of retinal thickening or occupying lesions in patients with VRL (21/106) was higher than that in patients with uveitis (1/86; P = 0.005; OR: 19.068; 95% CI: 2.455-148.265). The incidences of posterior vitreous detachment and retinal detachment were not significantly different between the 2 groups (P = 0.453 and P = 0.310, respectively). The centrifugal condensation pattern was more likely to be observed in patients with VRL (49/106) than in patients with uveitis (13/86; P < 0.001; OR: 4.831; 95% CI: 2.416-9.660).
B-scan ultrasonography might help to provide clues for the suspicion of VRL. Thickening or occupying lesions of the retina and centrifugal condensation pattern of vitreous haze might be suggestive of VRL.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
探讨玻璃体内视网膜淋巴瘤（VRL）在 B 型超声中的特征。
单中心病例对照研究。
共纳入 56 例经活检证实的 VRL 患者的 106 只眼和 59 例葡萄膜炎患者的 86 只眼。
对纳入眼行 B 型超声检查。评估超声征象以及一种特殊模式，称为离心浓缩，即在超声检查中玻璃体混浊呈周边高反射外观。
通过 B 型超声评估后玻璃体脱离、视网膜玻璃体粘连、玻璃体内混浊位置、视网膜增厚或占位性病变、视网膜脱离以及玻璃体混浊的离心浓缩模式。比较两组的这些征象发生率，计算比值比（ORs）。
VRL 患者（6/106）的视网膜玻璃体粘连发生率低于葡萄膜炎患者（20/86；P=0.001；OR：0.195；95%置信区间[CI]：0.073-0.522）。VRL 患者（21/106）的视网膜增厚或占位性病变发生率高于葡萄膜炎患者（1/86；P=0.005；OR：19.068；95%CI：2.455-148.265）。两组后玻璃体脱离和视网膜脱离的发生率无显著差异（P=0.453 和 P=0.310）。VRL 患者（49/106）更易观察到离心浓缩模式，而葡萄膜炎患者（13/86；P<0.001；OR：4.831；95%CI：2.416-9.660）。
B 型超声检查有助于提示 VRL 的怀疑。视网膜增厚或占位性病变和玻璃体混浊的离心浓缩模式可能提示 VRL。
