Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University and University Hospital Tuebingen, Tuebingen, Germany.
J Neurochem. 2024 Dec;168(12):3853-3871. doi: 10.1111/jnc.15983. Epub 2023 Oct 11.
Voltage-gated calcium channels (VGCC) are abundant in the central nervous system and serve a broad spectrum of functions, either directly in cellular excitability or indirectly to regulate Ca homeostasis. Ca ions act as one of the main connections in excitation-transcription coupling, muscle contraction and excitation-exocytosis coupling, including synaptic transmission. In recent years, many genes encoding VGCCs main α or additional auxiliary subunits have been associated with epilepsy. This review sums up the current state of knowledge on disease mechanisms and provides guidance on disease-specific therapies where applicable.
电压门控钙通道（VGCC）在中枢神经系统中大量存在，具有广泛的功能，既可以直接调节细胞兴奋性，也可以间接调节钙稳态。钙离子作为兴奋-转录偶联、肌肉收缩和兴奋-分泌偶联（包括突触传递）中的主要连接之一发挥作用。近年来，许多编码 VGCC 主要 α 亚基或其他辅助亚基的基因与癫痫有关。本综述总结了目前关于疾病机制的知识现状，并在适用的情况下为特定疾病的治疗提供了指导。
