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结肠癌患者中NPDC1表达及神经周围侵犯状态与临床病理特征的相关性

Correlation of NPDC1 Expression and Perineural Invasion Status with Clinicopathological Features in Patients with Colon Cancer.

作者信息

Li Jiannan, Sun Yao, Cao Lanqing, Wang Fang

机构信息

Department of Medical Microbiology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.

Department of Colorectal and Anal Surgery, Jilin University Second Hospital, Changchun, People's Republic of China.

出版信息

Int J Gen Med. 2023 Oct 6;16:4549-4563. doi: 10.2147/IJGM.S428590. eCollection 2023.

DOI:10.2147/IJGM.S428590
PMID:37822345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10563778/
Abstract

BACKGROUND

Colon cancer is a prevalent gastrointestinal malignancy that often exhibits distant metastasis, hindering the effectiveness of surgical interventions. In addition to well-known hematogenous and lymphatic metastasis, perineural invasion (PNI) has emerged as a significant mode of distant metastasis in colon tumors. PNI is closely associated with oncologic pain in advanced cancer patients, but the underlying mechanisms and associated biomarkers, which might be the novel therapeutic targets, remain poorly understood.

METHODS

In this study, we employed large databases and bioinformatics methods to identify genes strongly linked to PNI in colon cancer and investigated their involvement in tumor nerve invasion, progression mechanisms, and chemotherapy resistance. Immunohistochemical techniques were utilized to validate the expression of target genes in 384 colon cancer tissues, and their expression was correlated with clinicopathological characteristics and patient survival data in our hospital. Furthermore, we conducted a comprehensive literature review to explore the potential functions of the target genes and their associated genes.

RESULTS

Our screening revealed a significant correlation between neural proliferation differentiation and control-1 (NPDC1) expression and patient prognosis, suggesting a potential association with neural infiltration in colon cancer. Additionally, NPDC1 may promote tumorigenesis, progression, and chemoresistance through various related pathways.

CONCLUSION

Our study provides novel insights into the utility of NPDC1 as a predictive marker for PNI status, disease-free survival, and overall survival in patients with colon cancer, highlighting the prevalence of NPDC1 overexpression in patients with PNI in colon cancer.

摘要

背景

结肠癌是一种常见的胃肠道恶性肿瘤，常发生远处转移，影响手术干预的效果。除了众所周知的血行转移和淋巴转移外，神经周围浸润（PNI）已成为结肠癌远处转移的一种重要方式。PNI与晚期癌症患者的肿瘤疼痛密切相关，但其潜在机制和相关生物标志物（可能是新的治疗靶点）仍知之甚少。

方法

在本研究中，我们利用大型数据库和生物信息学方法，鉴定与结肠癌PNI密切相关的基因，并研究它们在肿瘤神经浸润、进展机制和化疗耐药中的作用。采用免疫组织化学技术验证384例结肠癌组织中靶基因的表达，并将其表达与我院患者的临床病理特征和生存数据相关联。此外，我们进行了全面的文献综述，以探索靶基因及其相关基因的潜在功能。

结果

我们的筛选显示神经增殖分化与调控因子-1（NPDC1）表达与患者预后显著相关，提示其可能与结肠癌的神经浸润有关。此外，NPDC1可能通过多种相关途径促进肿瘤发生、进展和化疗耐药。

结论

我们的研究为NPDC1作为结肠癌患者PNI状态、无病生存期和总生存期的预测标志物的应用提供了新的见解，突出了NPDC1在结肠癌PNI患者中过表达的普遍性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/177383001b6a/IJGM-16-4549-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/56e014cbece6/IJGM-16-4549-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/b196ca5d8e56/IJGM-16-4549-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/08975cab0f13/IJGM-16-4549-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/dabda8793d8d/IJGM-16-4549-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/4a7acbdf4ffc/IJGM-16-4549-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/177383001b6a/IJGM-16-4549-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/56e014cbece6/IJGM-16-4549-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/94a1764db9a7/IJGM-16-4549-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/a435fa5b1357/IJGM-16-4549-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/916c8282846e/IJGM-16-4549-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/b196ca5d8e56/IJGM-16-4549-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/08975cab0f13/IJGM-16-4549-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/dabda8793d8d/IJGM-16-4549-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/4a7acbdf4ffc/IJGM-16-4549-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbce/10563778/177383001b6a/IJGM-16-4549-g0009.jpg

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本文引用的文献

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The Impact of Matrix Metalloproteinase-11 Polymorphisms on Colorectal Cancer Progression and Clinicopathological Characteristics.
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Recurrence-Free Survival Outcomes Based on Novel Classification Combining Lymphovascular Invasion, Perineural Invasion, and T4 Status in Stage II-III Colon Cancer.基于将淋巴管侵犯、神经周围侵犯和T4状态相结合的新型分类的II-III期结肠癌无复发生存结果
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β-catenin correlates with the progression of colon cancers and berberine inhibits the proliferation of colon cancer cells by regulating the β-catenin signaling pathway.β-连环蛋白与结肠癌的进展相关，小檗碱通过调节β-连环蛋白信号通路抑制结肠癌细胞的增殖。
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