Institute of Biomedical Engineering (A.S., Y.W., Y.Z., S.L., J.L., M.R.), University of Toronto, Ontario, Canada.
Toronto General Research Institute, Ontario, Canada (A.S., Y.W., Y.Z., S.L., M.R.).
Arterioscler Thromb Vasc Biol. 2023 Dec;43(12):2241-2255. doi: 10.1161/ATVBAHA.123.318233. Epub 2023 Oct 12.
Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo microenvironment. Organ-on-a-chip systems have emerged as a promising approach for modeling vascular diseases by incorporating multiple cell types, mechanical and biochemical cues, and fluid flow in a microscale platform. This review provides an overview of recent advancements in engineering organ-on-a-chip systems for modeling vascular diseases, including the use of microfluidic channels, ECM (extracellular matrix) scaffolds, and patient-specific cells. We also discuss the limitations and future perspectives of organ-on-a-chip for modeling vascular diseases.
血管疾病，如动脉粥样硬化和血栓形成，是全球发病率和死亡率的主要原因。传统的用于研究血管疾病的体外模型存在局限性，因为它们不能完全再现体内微环境的复杂性。器官芯片系统作为一种有前途的方法，通过在微尺度平台上整合多种细胞类型、机械和生化线索以及流体流动，来模拟血管疾病。本文综述了最近在工程器官芯片系统模拟血管疾病方面的进展，包括使用微流控通道、细胞外基质 (ECM) 支架和患者特异性细胞。我们还讨论了器官芯片在模拟血管疾病方面的局限性和未来展望。
