College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
College of Food Science and Technology, Northwest University, Xi'an 710069, China.
ACS Appl Mater Interfaces. 2023 Oct 25;15(42):48882-48891. doi: 10.1021/acsami.3c08483. Epub 2023 Oct 12.
The natural biofilm on magnetosomes obtained from the biomineralization of magnetotactic bacteria, which replaced a complex chemical modification process on the surface of FeO, can be used as the organic component and copper(II) ions as the inorganic component to form organic-inorganic nanoflowers in phosphate systems. Characterization by scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating-sample magnetometry proved that magnetic nanoflowers loaded with silver ions (Ag/MN-Cu×NFs) were successfully fabricated. antibacterial experiments demonstrated that Ag/MN-Cu×NFs displayed strong antibacterial effects against and , with minimum inhibitory concentrations of 10 and 80 μg/mL, respectively. Ag/MN-Cu×NFs, which possessed good biocompatibility as confirmed by cytotoxicity and hemolysis tests, were able to promote wound healing in the face of bacterial infection without causing toxicity to major organs. Therefore, magnetosomes as a natural carrier have great application potential in the synthesis of multifunctional magnetosomes by direct hybridization with a target substance.
从趋磁细菌生物矿化中获得的磁小体的天然生物膜取代了 FeO 表面的复杂化学修饰过程，可以用作有机成分，铜(II)离子作为无机成分，在磷酸盐体系中形成有机-无机纳米花。通过扫描电子显微镜、傅里叶变换红外光谱和振动样品磁强计的表征证明，成功制备了负载银离子的磁性纳米花（Ag/MN-Cu×NFs）。抗菌实验表明，Ag/MN-Cu×NFs 对 和 表现出很强的抗菌作用，最小抑菌浓度分别为 10 和 80μg/mL。Ag/MN-Cu×NFs 通过细胞毒性和溶血试验证实具有良好的生物相容性，能够在不引起主要器官毒性的情况下促进细菌感染伤口的愈合。因此，磁小体作为一种天然载体，在通过与目标物质直接杂交合成多功能磁小体方面具有巨大的应用潜力。
