Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
J Am Geriatr Soc. 2024 Jan;72(1):209-218. doi: 10.1111/jgs.18627. Epub 2023 Oct 12.
The Successful Aging after Elective Surgery (SAGES) II Study was designed to examine the relationship between delirium and Alzheimer's disease and related dementias (AD/ADRD), by capturing novel fluid biomarkers, neuroimaging markers, and neurophysiological measurements. The goal of this paper is to provide the first complete description of the enrolled cohort, which details the baseline characteristics and data completion. We also describe the study modifications necessitated by the COVID-19 pandemic, and lay the foundation for future work using this cohort.
SAGES II is a prospective observational cohort study of community-dwelling adults age 65 and older undergoing major non-cardiac surgery. Participants were assessed preoperatively, throughout hospitalization, and at 1, 2, 6, 12, and 18 months following discharge to assess cognitive and physical functioning. Since participants were enrolled throughout the COVID-19 pandemic, procedural modifications were designed to reduce missing data and allow for high data quality.
About 420 participants were enrolled with a mean (standard deviation) age of 73.4 (5.6) years, including 14% minority participants. Eighty-eight percent of participants had either total knee or hip replacements; the most common surgery was total knee replacement with 210 participants (50%). Despite the challenges posed by the COVID-19 pandemic, which required the use of novel procedures such as video assessments, there were minimal missing interviews during hospitalization and up to 1-month follow-up; nearly 90% of enrolled participants completed interviews through 6-month follow-up.
While there are many longitudinal studies of older adults, this study is unique in measuring health outcomes following surgery, along with risk factors for delirium through the application of novel biomarkers-including fluid (plasma and cerebrospinal fluid), imaging, and electrophysiological markers. This paper is the first to describe the characteristics of this unique cohort and the data collected, enabling future work using this novel and important resource.
选择性手术后成功老龄化（SAGES）II 研究旨在通过捕获新的液体生物标志物、神经影像学标志物和神经生理学测量来研究谵妄与阿尔茨海默病和相关痴呆（AD/ADRD）之间的关系。本文的目的是提供入组队列的第一个完整描述，详细介绍基线特征和数据完成情况。我们还描述了 COVID-19 大流行所必需的研究修改，并为未来使用该队列奠定基础。
SAGES II 是一项针对 65 岁及以上社区居住成年人的前瞻性观察队列研究，他们正在接受非心脏大手术。参与者在术前、住院期间以及出院后 1、2、6、12 和 18 个月进行评估，以评估认知和身体功能。由于参与者在 COVID-19 大流行期间入组，因此设计了程序修改以减少数据缺失并确保高质量的数据。
大约有 420 名参与者入组，平均（标准差）年龄为 73.4（5.6）岁，包括 14%的少数族裔参与者。88%的参与者要么进行了全膝关节置换术，要么进行了全髋关节置换术；最常见的手术是全膝关节置换术，有 210 名参与者（50%）。尽管 COVID-19 大流行带来了挑战，需要采用视频评估等新程序，但在住院期间和 1 个月随访期间几乎没有缺失访谈；近 90%的入组参与者完成了 6 个月随访期间的访谈。
虽然有许多针对老年人的纵向研究，但这项研究是独特的，它通过应用新的生物标志物（包括液体（血浆和脑脊液）、成像和电生理学标志物）来测量手术后面的健康结果以及谵妄的风险因素。本文首次描述了这个独特队列的特征和收集的数据，为使用这个新颖而重要的资源进行未来的工作提供了条件。
