犬红细胞中存在镁离子和三磷酸腺苷依赖的钙外排泵的证据。

Evidence for a magnesium- and ATP-dependent calcium extrusion pump in dog erythrocytes.

作者信息

Brown A M

出版信息

Biochim Biophys Acta. 1979 Jun 13;554(1):195-203. doi: 10.1016/0005-2736(79)90018-x.

Abstract

Intact dog erythrocytes, whose Ca2+ permeability had been increased with A23187 still maintained intracellular Ca2+ below electrochemical equilibrium indicating that they could extrude Ca2+. This extrusion required no Na+ gradient but apparently depended on intracellular ATP and Mg2+ suggesting that it was mediated by an ATP-fuelled Ca2+ pump.

摘要

完整的犬红细胞，其Ca2+通透性已通过A23187增加，仍能将细胞内Ca2+维持在电化学平衡以下，这表明它们可以排出Ca2+。这种排出不需要Na+梯度，但显然依赖于细胞内的ATP和Mg2+，这表明它是由ATP驱动的Ca2+泵介导的。