Guo Yang, Dou Xia, Chen Xiao-Fan, Huang Cong, Zheng Ying-Jie, Yu Bo
Department of Dermatology, Institute of Dermatology, Peking University Shenzhen Hospital, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
Allergy Asthma Immunol Res. 2023 Sep;15(5):659-672. doi: 10.4168/aair.2023.15.5.659.
is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of , that is, methicillin-resistant (MRSA) and methicillin-sensitive (MSSA).
The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors.
In total, 2,941 adults were included. The prevalence rate of nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86-3.06) without significant heterogeneity in the association by demographic factors. No significant associations between nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64-6.54) for MRSA, although with borderline significant.
Nasal colonization of s was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting for the anterior nares should be considered in preventing and treating eczema.
[细菌名称]是湿疹的关键致病细菌。[细菌名称]鼻腔定植与湿疹之间的关系尚未得到充分研究。我们旨在评估[细菌名称]鼻腔定植与多个身体部位湿疹之间的关联，包括持续性湿疹和曾报告过的湿疹。我们还进一步研究了湿疹与[细菌名称]不同亚型之间的关联，即耐甲氧西林[细菌名称]（MRSA）和甲氧西林敏感[细菌名称]（MSSA）。
使用来自美国国家健康与营养检查调查的真实世界数据。使用调查加权多项逻辑回归模型计算关联，并在按人口统计学因素分层的亚组中进一步计算。
总共纳入了2941名成年人。持续性手部湿疹成年人中[细菌名称]鼻腔携带率（51.0%）显著高于曾报告过手部湿疹的成年人（23.3%）和从未患过湿疹的成年人（26.9%）。[细菌名称]鼻腔定植与持续性手部湿疹风险增加约两倍相关（不同模型中的比值比范围：2.86 - 3.06），且按人口统计学因素分析该关联无显著异质性。未观察到[细菌名称]鼻腔定植与其他身体部位的持续性湿疹或多个身体部位（包括手部）曾报告过的湿疹之间存在显著关联。此外，观察到MSSA鼻腔定植与持续性手部湿疹之间存在类似的显著关联；MRSA的关联更强（不同模型中的比值比范围：4.64 - 6.54），尽管具有临界显著性。
[细菌名称]鼻腔定植与持续性手部湿疹风险增加相关。我们的研究结果表明，在预防和治疗湿疹时应考虑针对前鼻孔[细菌名称]的预防措施。
