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特应性皮炎患者的[具体内容缺失，无法准确翻译]定植：揭示未知的尝试。

Colonization With in Atopic Dermatitis Patients: Attempts to Reveal the Unknown.

作者信息

Ogonowska Patrycja, Gilaberte Yolanda, Barańska-Rybak Wioletta, Nakonieczna Joanna

机构信息

Laboratory of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.

Department of Dermatology, University Hospital Miguel Servet, Zaragoza, Spain.

出版信息

Front Microbiol. 2021 Jan 11;11:567090. doi: 10.3389/fmicb.2020.567090. eCollection 2020.

DOI:10.3389/fmicb.2020.567090
PMID:33505363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7830525/
Abstract

Atopic dermatitis (AD) patients are massively colonized with () in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived . Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

摘要

特应性皮炎（AD）患者的皮损和非皮损皮肤中大量定植有（）。皮肤感染若不治疗可能会发展为全身性感染。有趣的是，与健康人群相比，AD患者中耐多药（MRSA）的发生率更高，这使得治疗更具挑战性。关于伴随和/或引发AD发作的（）的特定遗传背景信息，对于可能的治疗方案开发具有重要意义。在本综述中，我们总结了AD皮肤中（）的总体流行数据，以及可能与湿疹发作相关的特定克隆的流行情况。我们特别关注葡萄球菌肠毒素作为AD衍生（）流行病学中重要毒力因子的存在和作用。此外，我们总结了目前以及未来可能有用的抗葡萄球菌治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/175795d0358f/fmicb-11-567090-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/4f6cb166ebac/fmicb-11-567090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/b6ea23df8cac/fmicb-11-567090-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/7aa9175a8482/fmicb-11-567090-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/7a6eda5c7131/fmicb-11-567090-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/175795d0358f/fmicb-11-567090-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/4f6cb166ebac/fmicb-11-567090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/b6ea23df8cac/fmicb-11-567090-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/7aa9175a8482/fmicb-11-567090-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/7a6eda5c7131/fmicb-11-567090-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/175795d0358f/fmicb-11-567090-g005.jpg

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[1]
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Burns Trauma. 2025-5-3

[2]
Strains in Atopic Dermatitis in Children: Toxins Production and Resistance Properties.

Life (Basel). 2025-7-17

[3]
Monolaurin inhibits antibiotic-resistant Staphylococcus aureus in patients with atopic dermatitis.

Sci Rep. 2025-7-2

[4]
Unique dermal bacterial signature differentiates atopic dermatitis skin from healthy.

mSphere. 2025-6-25

[5]
An Overview of Atopic Dermatitis Disease Burden, Pathogenesis, and the Current Treatment Landscape: Recommendations for Appropriate Utilization of Systemic Therapies.

J Clin Aesthet Dermatol. 2025-3

[6]
Global changes in virulence and metabolism during colonization of healthy skin.

Infect Immun. 2025-4-8

[7]
Flavonoids as Natural Anti-Inflammatory Agents in the Atopic Dermatitis Treatment.

Pharmaceutics. 2025-2-15

[8]
The Therapeutic Potential of Kiwi Extract as a Source of Cysteine Protease Inhibitors on DNCB-Induced Atopic Dermatitis in Mice and Human Keratinocyte HaCaT Cells.

Int J Mol Sci. 2025-2-12

[9]
Understanding host's response to staphylococcal scalded skin syndrome.

Acta Paediatr. 2025-2

[10]
colonizing the skin microbiota of adults with severe atopic dermatitis exhibits genomic diversity and convergence in biofilm traits.

Biofilm. 2024-9-19

本文引用的文献

[1]
Human Keratinocyte Response to Superantigens.

mSphere. 2020-10-7

[2]
Self-administered daylight-activated photodynamic therapy for the treatment of hand eczema: A prospective proof-of-concept study.

Dermatol Ther. 2020-11

[3]
Selective JAK1 Inhibitors for the Treatment of Atopic Dermatitis: Focus on Upadacitinib and Abrocitinib.

Am J Clin Dermatol. 2020-12

[4]
Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet. 2020-7-25

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Photodynamic therapy in dermatology: Beyond current indications.

Dermatol Ther. 2020-11

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Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials.

Br J Dermatol. 2020-8

[7]
Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis: A Randomized Clinical Trial.

JAMA Dermatol. 2020-2-1

[8]
Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.

Infect Immun. 2020-1-22

[9]
Microbe-host interplay in atopic dermatitis and psoriasis.

Nat Commun. 2019-10-16

[10]
Pulsed-Field Gel Electrophoresis Typing of Staphylococcus aureus Strains.

Methods Mol Biol. 2020

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