第二次接种新冠疫苗五个月后新冠病毒抗刺突IgG抗体的评估。
Evaluation of Covid-19 anti-spike IgG antibody five months after the second Covid-19 vaccination.
作者信息
Rafie Reyhaneh Alipoor, Azimi Leila, Armin Shahnaz, Aghamohammadi Amirali, Karimi Abdollah, Fallah Fatemeh, Khodaei Hannan, Mansour Ghanaie Roxana, Alebouyeh Masoud
机构信息
Department of Infectious Diseases, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Pediatric Infections Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
GMS Hyg Infect Control. 2023 Sep 7;18:Doc20. doi: 10.3205/dgkh000446. eCollection 2023.
BACKGROUND
Studies in different communities have shown significant differences in IgG antibody titers in the time period after the first and second doses of the vaccines. This study aimed to serologically evaluate the IgG anti-spike antibody titer five months after injection of the second COVID-19 vaccine in healthcare workers.
MATERIALS AND METHOD
This study was performed in healthcare personnel for whom five months had passed since their second anti-Covid-19 vaccination. The level of IgG antibody against SARS-CoV-2 spike protein was measured by ELISA. Healthcare workers in Mofid Children's hospital received three brands of vaccines: Sputnik V, Sinopharm, and AstraZeneca.
RESULTS
The mean titer of anti-spike IgG was 4.3±2.29 units. The percentage of positive cases of the antibody was estimated to be 96.4%. The titer of anti-spike IgG antibody was dependent on both the occupational area and a positive history of Covid-19 disease.
CONCLUSION
About 96.4% of the staff vaccinated against Covid-19 had a high titer of anti-spike IgG antibody even five months after inoculation of the second dose. The field of occupational can affect the level of antibody present.
背景
不同社区的研究表明，在接种第一剂和第二剂疫苗后的时间段内，IgG抗体滴度存在显著差异。本研究旨在对医护人员接种第二剂新冠疫苗五个月后的IgG抗刺突抗体滴度进行血清学评估。
材料与方法
本研究针对自第二次接种新冠疫苗已过去五个月的医护人员开展。采用酶联免疫吸附测定法（ELISA）检测针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的IgG抗体水平。莫菲德儿童医院的医护人员接种了三种品牌的疫苗：卫星五号、国药集团疫苗和阿斯利康疫苗。
结果
抗刺突IgG的平均滴度为4.3±2.29个单位。抗体阳性病例的百分比估计为96.4%。抗刺突IgG抗体的滴度既取决于职业领域，也取决于新冠疾病的阳性病史。
结论
即使在接种第二剂疫苗五个月后，约96.4%接种新冠疫苗的工作人员仍具有高滴度的抗刺突IgG抗体。职业领域会影响抗体水平。
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