Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Cancer Translational Medicine Research Center, The Second Hospital, Dalian Medical University, Dalian, China.
Clin Transl Med. 2023 Oct;13(10):e1433. doi: 10.1002/ctm2.1433.
Aggressive brain tumours, whether primary gliomas or secondary metastases, are characterised by hypervascularisation and are fatal. Recent research has emphasised the crucial involvement of endothelial cells (ECs) in all brain tumour genesis and development events, with various patterns and underlying mechanisms identified.
Here, we highlight recent advances in knowledge about the contributions of ECs to brain tumour development, providing a comprehensive summary including descriptions of interactions between ECs and tumour cells, the heterogeneity of ECs and new models for research on ECs in brain malignancies. We also discuss prospects for EC targeting in novel therapeutic approaches.
Interventions targeting ECs, as an adjunct to other therapies (e.g. immunotherapies, molecular-targeted therapies), have shown promising clinical efficacy due to the high degree of vascularisation in brain tumours. Developing precise strategies to target tumour-associated vessels based on the heterogeneity of ECs is expected to improve anti-vascular efficacy.
侵袭性脑肿瘤，无论是原发性神经胶质瘤还是继发性转移瘤，其特征是血管过度增生，且具有致命性。最近的研究强调了内皮细胞（EC）在所有脑肿瘤发生和发展事件中的关键作用，并确定了各种模式和潜在机制。
在这里，我们重点介绍了关于 EC 对脑肿瘤发展贡献的最新知识进展，提供了全面的综述，包括描述 EC 与肿瘤细胞之间的相互作用、EC 的异质性以及脑恶性肿瘤中 EC 研究的新模型。我们还讨论了针对 EC 进行靶向治疗的前景。
由于脑肿瘤中血管生成程度高，针对 EC 的干预措施（如免疫疗法、分子靶向疗法）作为其他疗法的辅助手段，已显示出有希望的临床疗效。基于 EC 的异质性开发针对肿瘤相关血管的精确靶向策略，有望提高抗血管生成疗效。
