[疫苗接种对瓦隆地区养老院工作人员唾液检测阳性率的早期影响]
[Early effect of vaccination on the positivity rate of salivary tests performed on nursing home staff in the Walloon Region].
作者信息
Seddiki Lamia, Rosas Angel, Savsin Muhammet, Collart Philippe, Van Malderen Carine, Dubourg Dominique
机构信息
Direction de la Recherche, de la Statistique et de la Veille des politiques, Agence pour une Vie de Qualité (AViQ), Belgique.
Délégation générale COVID-19, Gouvernement wallon, Belgique.
出版信息
Rev Med Liege. 2023 Oct;78(10):540-546.
UNLABELLED
In Belgium, nursing homes (NH) were disproportionately affected by the SARS-CoV-2 pandemic. The objective of this study was to compare the risk of SARS-CoV-2 infection in vaccinated and unvaccinated staff members.
METHODS
This was a prospective cohort study conducted between February 1 and April 02, 2021, in 99 nursing homes (NHs) in the Walloon Region, a few weeks after the start of the vaccination campaign. A mixed-effects logistic regression analysis was performed to assess the relationship between COVID results of molecular tests on saliva samples of the NHs' staff and their vaccination status.
RESULTS
Only 32 (0,1 %) of 39 267 saliva tests were positive. Logistic analysis showed that unvaccinated nursing home staff were 4 times more likely to develop COVID-19 than vaccinated staff during the study period.
CONCLUSION
This study demonstrated an early decreased risk of infection in vaccinated NHs staff. Saliva tests were designed to be convenient, less expensive and non-invasive, and could be considered as an alternative to nasopharyngeal tests.
未标注
在比利时，养老院受到新冠疫情的影响尤为严重。本研究的目的是比较接种疫苗和未接种疫苗的工作人员感染新冠病毒的风险。
方法
这是一项前瞻性队列研究，于2021年2月1日至4月2日在瓦隆地区的99家养老院进行，此时距离疫苗接种运动开始已有几周时间。进行了混合效应逻辑回归分析，以评估养老院工作人员唾液样本分子检测的新冠结果与其疫苗接种状况之间的关系。
结果
在39267次唾液检测中，只有32次（0.1%）呈阳性。逻辑分析表明，在研究期间，未接种疫苗的养老院工作人员感染新冠病毒的可能性是接种疫苗工作人员的4倍。
结论
本研究表明，接种疫苗的养老院工作人员感染风险早期有所降低。唾液检测设计得方便、成本较低且无创，可被视为鼻咽检测的替代方法。
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