Alwhaibi Monira
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11437, Saudi Arabia.
Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh 11437, Saudi Arabia.
Healthcare (Basel). 2023 Sep 27;11(19):2637. doi: 10.3390/healthcare11192637.
Adults with gastroesophageal reflux disease (GERD) are susceptible to mental disorders that might significantly affect their health-related quality of life (HRQoL). Therefore, the purpose of this study was to evaluate how HRQoL in individuals with GERD is related to coexisting anxiety and depression.
A cross sectional study was conducted among 3068 adult patients 22 years of age and older with GERD diagnoses have been identified using the data from the Medical Expenditure Panel Survey from 2017 to 2020 for United States adults. Data are gathered by MEPS using an overlapping panel design over a period of two and a half years. HRQoL was established using the Physical and Mental Component Summary (PCS & MCS) values from the SF-12. Multivariate forward linear regression analysis was used to assess the relationship between anxiety, depression, and HRQoL in people with GERD after accounting for various factors.
Of the 3068 people with GERD who had been identified, 56.4% were women, 59.4% were in their 50s or 60s and 64.8% were employed. Thirteen per cent of people with GERD had depression, thirteen per cent had anxiety, and ten per cent had both. Adults with concurrent anxiety and depression had the lowest mean PCS and MCS scores compared to those with GERD. After adjusting for all independent factors, GERD patients with anxiety (MCS = -10.819, -value < 0.0001), depression (MCS = -6.395, -value < 0.0001), and both (MCS= -42.869, -value < 0.0001) had substantially worse HRQoL than those without these comorbidities. Notably, better HRQoL scores were positively associated with marital status, employment, perceived overall health, and physical activity.
The results from this nationally representative sample shed insight into the relationships between low HRQoL and anxiety and depression among individuals with GERD. It also demonstrated the detrimental impacts of co-occurring chronic illnesses, low socioeconomic status, and the positive benefits of employment and exercise on HRQoL. This study emphasizes the clinical, policy, and public health implications for better healthcare, allocation of resources, and promotion of lifestyle modifications to improve the HRQoL in patients with GERD.
患有胃食管反流病（GERD）的成年人易患精神障碍，这可能会显著影响他们的健康相关生活质量（HRQoL）。因此，本研究的目的是评估GERD患者的HRQoL与并存的焦虑和抑郁之间的关系。
利用2017年至2020年美国成年人医疗支出面板调查的数据，对3068名22岁及以上被诊断为GERD的成年患者进行了一项横断面研究。医疗支出面板调查（MEPS）采用重叠面板设计，在两年半的时间内收集数据。使用SF-12的身体和心理成分总结（PCS和MCS）值来确定HRQoL。在考虑各种因素后，采用多元向前线性回归分析来评估GERD患者中焦虑、抑郁与HRQoL之间的关系。
在已确定的3068名GERD患者中，56.4%为女性，59.4%年龄在50多岁或60多岁，64.8%有工作。13%的GERD患者患有抑郁症，13%患有焦虑症，10%两者都有。与单纯患有GERD的患者相比，同时患有焦虑和抑郁的成年人的PCS和MCS平均得分最低。在对所有独立因素进行调整后，患有焦虑症（MCS = -10.819，p值<0.0001）、抑郁症（MCS = -6.395，p值<0.0001）以及两者都有的GERD患者（MCS = -42.869，p值<0.0001）的HRQoL明显比没有这些合并症的患者差。值得注意的是，较好的HRQoL得分与婚姻状况、就业、总体健康感知和体育活动呈正相关。
这个具有全国代表性的样本的结果揭示了GERD患者中低HRQoL与焦虑和抑郁之间的关系。它还证明了并存的慢性疾病、低社会经济地位的有害影响，以及就业和运动对HRQoL的积极益处。本研究强调了在临床、政策和公共卫生方面的意义，即需要改善医疗保健、资源分配，并促进生活方式的改变，以提高GERD患者的HRQoL。
