Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Front Public Health. 2023 Oct 4;11:1241800. doi: 10.3389/fpubh.2023.1241800. eCollection 2023.
Adults who suffer from migraines are highly susceptible to mental illnesses that may have significant association with their HRQoL. Therefore, this study aimed to investigate how anxiety and depression related to HRQoL in adults with Migraine.
Data from the Medical Expenditure Panel Survey for 2017 to 2020 were used to identify adult patients 18 years of age and older with a migraine diagnosis. The Physical and Mental Component Summary (PCS & MCS) scores from the SF-12 were used to calculate HRQoL. To adjust for a wide range of variables, multivariate linear regressions were used to evaluate the association between depression and anxiety and HRQoL among adults with migraine.
Among the 1,713 identified adults with migraines, 11.2% experienced depression, 14.6% experienced anxiety, and 13.7% had both conditions. Compared to migraineurs who had only migraine, adults with comorbid depression and anxiety had the lowest mean scores on the PCS and MCS. Additionally, migraineurs who had depression had significantly lower HRQoL MCS scores (depression: β = -7.552, < 0.001), and those with anxiety had significantly lower HRQoL MCS scores (anxiety: β = -4.844, p < 0.001) compared to those without these comorbidities. Notably, individuals with migraines who exercise had higher scores on both PCS and MCS than those who did not exercise.
This nationally representative sample provides insights into the associations between depression and anxiety with poor HRQoL among individuals with migraines. Additionally, it revealed the negative impact of concurrent chronic diseases, and poor socioeconomic status on HRQoL, while emphasizing the beneficial effects of regular exercise. This study highlights the clinical, policy, and public health implications for improving healthcare planning, resource allocation, and promoting lifestyle changes to reduce depression and anxiety in migraine sufferers.
患有偏头痛的成年人极易患上精神疾病，这些疾病可能与他们的健康相关生活质量（HRQoL）有重大关联。因此，本研究旨在探讨焦虑和抑郁与偏头痛成年人的 HRQoL 之间的关系。
使用 2017 年至 2020 年的医疗支出面板调查数据，确定年龄在 18 岁及以上的患有偏头痛的成年患者。使用 SF-12 的身体和心理成分综合评分（PCS 和 MCS）来计算 HRQoL。为了调整广泛的变量，使用多元线性回归来评估成年人偏头痛患者中抑郁和焦虑与 HRQoL 之间的关联。
在确定的 1713 名患有偏头痛的成年人中，11.2%患有抑郁，14.6%患有焦虑，13.7%同时患有这两种疾病。与仅有偏头痛的偏头痛患者相比，患有共病性抑郁和焦虑的成年人在 PCS 和 MCS 上的平均得分最低。此外，患有抑郁的偏头痛患者的 HRQoL MCS 得分明显较低（抑郁：β=-7.552，<0.001），而患有焦虑的偏头痛患者的 HRQoL MCS 得分明显较低（焦虑：β=-4.844，p<0.001）与没有这些合并症的患者相比。值得注意的是，患有偏头痛且经常锻炼的个体在 PCS 和 MCS 上的得分均高于不锻炼的个体。
这项具有全国代表性的样本研究提供了关于抑郁和焦虑与偏头痛患者 HRQoL 较差之间的关联的见解。此外，它揭示了并发慢性疾病和较差的社会经济状况对 HRQoL 的负面影响，同时强调了定期锻炼的有益影响。这项研究强调了改善医疗保健规划、资源分配和促进生活方式改变以减少偏头痛患者抑郁和焦虑的临床、政策和公共卫生意义。
