Piatti Diletta, Marconi Riccardo, Angeloni Simone, Caprioli Giovanni, Maggi Filippo, Ribatti Emanuele, Cattaneo Vittorio, Sagratini Gianni
Chemistry Interdisciplinary Project (Chip) research centre, School of Pharmacy, University of Camerino, Camerino, Italy.
Research and Development Department, Indena SpA, Milan, Italy.
Nat Prod Res. 2025 Feb;39(3):438-443. doi: 10.1080/14786419.2023.2269595. Epub 2023 Oct 13.
Alkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from . In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. presented hyoscyamine and scopolamine, the first one ranged from 1466 to 5117 mg/Kg DW while the second one ranged from 140 to 1743 mg/Kg DW. In , hyoscyamine was not found while scopolamine ranged from 430 to 8980 mg/Kg DW. On the contrary and did not contain any trace of these alkaloids. This is the first work in which different parts of four Solanaceae were analysed for their hyoscyamine and scopolamine content.
生物碱是一类自古以来就备受关注的次生代谢产物。许多茄科植物是托烷生物碱的丰富来源，如主要从……中获得的莨菪碱和东莨菪碱。在本研究中，开发了一种使用XBridge苯基柱的HPLC-DAD方法来定量东莨菪碱和莨菪碱，这两种分子在制药工业中用于治疗胃部或肠道疾病。……给出了莨菪碱和东莨菪碱的含量，前者范围为1466至5117毫克/千克干重，而后者范围为140至1743毫克/千克干重。在……中，未发现莨菪碱，而东莨菪碱范围为430至8980毫克/千克干重。相反，……和……不含这些生物碱的任何痕迹。这是首次对四种茄科植物的不同部位进行莨菪碱和东莨菪碱含量分析的工作。
