T细胞受体β链进化中的基因校正。
Gene correction in the evolution of the T cell receptor beta chain.
作者信息
Jouvin-Marche E, Heller M, Rudikoff S
出版信息
J Exp Med. 1986 Dec 1;164(6):2083-8. doi: 10.1084/jem.164.6.2083.
Abstract
Mutational mechanisms operating at the T cell receptor beta chain locus have been examined by comparison of the CT beta 1 and CT beta 2 gene sequences from Mus pahari, believed to be the oldest living species in the genus Mus, with those of inbred mice. Results indicate that a gene correction event independent of that suggested to have occurred in inbred mice has homogenized the M. pahari CT beta exon 1 sequences, minimizing diversity in this region of the molecule. These observations suggest that correction events such as gene conversion may occur frequently, even in pauci-gene families with as few as two members, and therefore play a significant role in gene diversification or homogenization of small as well as large gene families.
摘要
通过比较来自印度小鼠（被认为是小鼠属现存最古老的物种）的CT beta 1和CT beta 2基因序列与近交系小鼠的基因序列，研究了在T细胞受体β链基因座上起作用的突变机制。结果表明，与近交系小鼠中所推测发生的事件无关的基因校正事件，使印度小鼠CT beta外显子1序列同质化，将该分子这一区域的多样性降至最低。这些观察结果表明，诸如基因转换之类的校正事件可能频繁发生，即使在成员少至两个的寡基因家族中也是如此，因此在小基因家族和大基因家族的基因多样化或同质化过程中发挥着重要作用。
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