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1
Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.人类T细胞受体β链基因座Dβ2-Jβ2区域的序列
Nucleic Acids Res. 1985 Sep 25;13(18):6651-61. doi: 10.1093/nar/13.18.6651.
2
Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element.人T细胞受体β链多样性区段的鉴定及其与类似小鼠元件的比较。
Nature. 1984;311(5984):387-9. doi: 10.1038/311387a0.
3
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain.人类T细胞受体α链可变区、连接区和恒定区基因的组织与序列
Nature. 1985;316(6031):837-40. doi: 10.1038/316837a0.
4
Genomic organization of the genes encoding mouse T-cell receptor alpha-chain.编码小鼠T细胞受体α链的基因的基因组组织
Nature. 1985;316(6031):832-6. doi: 10.1038/316832a0.
5
Evolutionarily conserved organization and sequences of germline diversity and joining regions of the rabbit T-cell receptor beta 2 chain.兔T细胞受体β2链种系多样性及连接区的进化保守组织与序列
Mol Immunol. 1991 Aug;28(8):881-8. doi: 10.1016/0161-5890(91)90052-l.
6
Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.异常重组产物源于人类T细胞抗原受体β链基因的异常DNA重排。
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4890-4. doi: 10.1073/pnas.83.13.4890.
7
DNA segment containing C beta 1, a gene for the constant region of the beta chain of the T-cell antigen receptor, was inserted into chromosome 6 in cells from one patient with human T-cell leukemia.包含T细胞抗原受体β链恒定区基因C beta 1的DNA片段，被插入到一名人类T细胞白血病患者细胞的6号染色体中。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4264-7. doi: 10.1073/pnas.84.12.4264.
8
Localization of a T-cell receptor diversity-region element.一种T细胞受体多样性区域元件的定位
Nature. 1984;310(5976):421-3. doi: 10.1038/310421a0.
9
Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.人类T细胞受体β链的多样性、连接和恒定区基因的组织与序列
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8624-8. doi: 10.1073/pnas.82.24.8624.
10
Somatic recombination in a murine T-cell receptor gene.小鼠T细胞受体基因中的体细胞重组。
Nature. 1984;309(5966):322-6. doi: 10.1038/309322a0.

引用本文的文献

1
Rare occurrence of classical Hodgkin's disease as a T cell lymphoma.经典型霍奇金淋巴瘤罕见地表现为T细胞淋巴瘤。
J Exp Med. 2000 Jan 17;191(2):387-94. doi: 10.1084/jem.191.2.387.
2
Conservation of sequence in recombination signal sequence spacers.重组信号序列间隔区中序列的保守性。
Nucleic Acids Res. 1994 May 25;22(10):1785-96. doi: 10.1093/nar/22.10.1785.
3
Diversity and structure of human T-cell receptor beta-chain variable region genes.人类T细胞受体β链可变区基因的多样性与结构
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6598-602. doi: 10.1073/pnas.83.17.6598.
4
Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.异常重组产物源于人类T细胞抗原受体β链基因的异常DNA重排。
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4890-4. doi: 10.1073/pnas.83.13.4890.
5
A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor.由人类T细胞受体β链基因中的倒位机制产生的连接多样性连接复合体和可变多样性复合体。
Nucleic Acids Res. 1986 Jun 25;14(12):4899-909. doi: 10.1093/nar/14.12.4899.
6
Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen.人类T淋巴细胞抗原受体β链多样性的产生
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4456-60. doi: 10.1073/pnas.83.12.4456.
7
Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments.人类Jδ-Cδ/Jα-Cα基因座内的复杂重排以及Jα片段之间的异常重组。
EMBO J. 1988 Jun;7(6):1661-8. doi: 10.1002/j.1460-2075.1988.tb02993.x.
8
Genetic recombination within the human T-cell receptor alpha-chain gene complex.人类T细胞受体α链基因复合体内的基因重组。
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9089-93. doi: 10.1073/pnas.84.24.9089.
9
Molecular genotyping of human T-cell antigen receptor variable gene segments.人类T细胞抗原受体可变基因片段的分子基因分型
Immunogenetics. 1986;24(4):259-66. doi: 10.1007/BF00364530.
10
Modification of T cell receptor beta chain gene: the J2 region but not the J1 region of the T cell receptor beta chain gene is hypomethylated in human B cells and monocytes.T细胞受体β链基因的修饰：在人类B细胞和单核细胞中，T细胞受体β链基因的J2区域而非J1区域发生低甲基化。
Nucleic Acids Res. 1988 Mar 25;16(5):2149-63. doi: 10.1093/nar/16.5.2149.

本文引用的文献

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Human immunoglobulin D segments encoded in tandem multigenic families.串联多基因家族中编码的人类免疫球蛋白D区段。
Nature. 1981 Dec 17;294(5842):631-5. doi: 10.1038/294631a0.
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An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences.一个用于比较和比对核酸及氨基酸序列的交互式图形程序。
Nucleic Acids Res. 1982 May 11;10(9):2951-61. doi: 10.1093/nar/10.9.2951.
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Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.免疫球蛋白重链多样性DNA片段的组织、结构与组装
J Exp Med. 1982 Jan 1;155(1):201-18. doi: 10.1084/jem.155.1.201.
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Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes.免疫球蛋白重链基因多样性DNA片段（D）的鉴定及核苷酸序列
Nature. 1981 Apr 16;290(5807):562-5. doi: 10.1038/290562a0.
5
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.免疫球蛋白重链可变区基因由三段DNA片段组成：VH、D和JH。
Cell. 1980 Apr;19(4):981-92. doi: 10.1016/0092-8674(80)90089-6.
6
Localization of a T-cell receptor diversity-region element.一种T细胞受体多样性区域元件的定位
Nature. 1984;310(5976):421-3. doi: 10.1038/310421a0.
7
Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.小鼠T细胞抗原受体：编码β多肽的恒定区和连接区基因片段的结构与组织
Cell. 1984 Jul;37(3):1101-10. doi: 10.1016/0092-8674(84)90444-6.
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Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element.人T细胞受体β链多样性区段的鉴定及其与类似小鼠元件的比较。
Nature. 1984;311(5984):387-9. doi: 10.1038/311387a0.
9
Graphic methods to determine the function of nucleic acid sequences.用于确定核酸序列功能的图解方法。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38. doi: 10.1093/nar/12.1part2.521.
10
Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.T细胞受体β链恒定区和连接区基因的基因组组织与序列
Nature. 1984;310(5976):387-91. doi: 10.1038/310387a0.

人类T细胞受体β链基因座Dβ2-Jβ2区域的序列

Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.

作者信息

Tunnacliffe A, Rabbitts T H

出版信息

Nucleic Acids Res. 1985 Sep 25;13(18):6651-61. doi: 10.1093/nar/13.18.6651.

DOI:10.1093/nar/13.18.6651
PMID:2997718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321983/
Abstract

We have sequenced the region encompassing a D beta 2 segment and the J beta 2 segments of the human T-cell antigen receptor beta-chain genes. The D beta 2 element lies about 650 base pairs upstream of a cluster of seven potentially functional J beta 2 sequences and one J beta 2 pseudogene. Examination of human beta-chain cDNA sequences which involve rearranged D beta 2 and J beta 2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J joining. Further, we present evidence for possible somatic mutation in active J beta 2 segments.

摘要

我们已对包含人类T细胞抗原受体β链基因的Dβ2片段和Jβ2片段的区域进行了测序。Dβ2元件位于七个潜在功能性Jβ2序列和一个Jβ2假基因簇上游约650个碱基对处。对涉及重排的Dβ2和Jβ2元件的人类β链cDNA序列的研究表明，在D-J连接过程中可发生N区以及连接多样性。此外，我们提供了活性Jβ2片段中可能存在体细胞突变的证据。