人类T细胞受体β链基因座Dβ2-Jβ2区域的序列
Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.
作者信息
Tunnacliffe A, Rabbitts T H
出版信息
Nucleic Acids Res. 1985 Sep 25;13(18):6651-61. doi: 10.1093/nar/13.18.6651.
Abstract
We have sequenced the region encompassing a D beta 2 segment and the J beta 2 segments of the human T-cell antigen receptor beta-chain genes. The D beta 2 element lies about 650 base pairs upstream of a cluster of seven potentially functional J beta 2 sequences and one J beta 2 pseudogene. Examination of human beta-chain cDNA sequences which involve rearranged D beta 2 and J beta 2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J joining. Further, we present evidence for possible somatic mutation in active J beta 2 segments.
摘要
我们已对包含人类T细胞抗原受体β链基因的Dβ2片段和Jβ2片段的区域进行了测序。Dβ2元件位于七个潜在功能性Jβ2序列和一个Jβ2假基因簇上游约650个碱基对处。对涉及重排的Dβ2和Jβ2元件的人类β链cDNA序列的研究表明，在D-J连接过程中可发生N区以及连接多样性。此外，我们提供了活性Jβ2片段中可能存在体细胞突变的证据。
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