Department of Rheumatology with Subdepartment of Internal Medicine, Medical University of Lodz, 90-549 Lodz, Poland.
Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, 90-549 Lodz, Poland.
Nutrients. 2021 Feb 22;13(2):701. doi: 10.3390/nu13020701.
Gout, known as "the disease of the kings", is the most frequent type of arthritis. It results from sustained hyperuricemia that leads to monosodium urate crystal deposition in joint structures and soft tissue. Environmental factors such as diet affect the incidence of gout; there is a known relationship between the occurrence of an acute attack of gout and the consumption of alcohol and meat; and a low purine diet is a widely recognized nonpharmacological method of supplementing the treatment and preventing recurrence of arthritis. This review aims to summarize the current knowledge about the role of vitamin C in prevention and treatment of gout. A PubMed/Medline database search on the role of vitamin C in purine metabolism was done. Reports from in vitro and animal studies seem to be promising and to allow explanation of the physiological relationship between vitamin C and uric acid. Most epidemiological studies indicate a significant correlation between high vitamin C intake and lower serum uric acid levels. Despite promising observations, there are few observational and interventional studies, and their results do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout.
痛风，又称“王者之疾”，是最常见的关节炎类型。它是由持续的高尿酸血症引起的，导致单钠尿酸盐晶体在关节结构和软组织中的沉积。环境因素如饮食会影响痛风的发病率；已知痛风急性发作的发生与饮酒和肉类摄入有关；低嘌呤饮食是一种广泛认可的非药物治疗方法，可补充关节炎的治疗和预防复发。本综述旨在总结维生素 C 在预防和治疗痛风中的作用的现有知识。对维生素 C 在嘌呤代谢中的作用进行了 PubMed/Medline 数据库检索。来自体外和动物研究的报告似乎很有前景，并能够解释维生素 C 和尿酸之间的生理关系。大多数流行病学研究表明，高维生素 C 摄入与血清尿酸水平降低之间存在显著相关性。尽管有一些有前景的观察结果，但观察性和干预性研究较少，其结果并不能明确界定高每日维生素 C 摄入量在预防痛风发展和复发方面的益处。
