Bacterial Pathogenesis and Antimicrobial Resistance Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; email:
National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Annu Rev Pathol. 2024 Jan 24;19:203-226. doi: 10.1146/annurev-pathmechdis-051122-111408. Epub 2023 Oct 13.
Bacterial pathogens undergo remarkable adaptive change in response to the selective forces they encounter during host colonization and infection. Studies performed over the past few decades have demonstrated that many general evolutionary processes can be discerned during the course of host adaptation, including genetic diversification of lineages, clonal succession events, convergent evolution, and balanced fitness trade-offs. In some cases, elevated mutation rates resulting from mismatch repair or proofreading deficiencies accelerate evolution, and active mobile genetic elements or phages may facilitate genome plasticity. The host immune response provides another critical component of the fitness landscapes guiding adaptation, and selection operating on pathogens at this level may lead to immune evasion and the establishment of chronic infection. This review summarizes recent advances in this field, with a special focus on different forms of bacterial genome plasticity in the context of infection, and considers clinical consequences of adaptive changes for the host.
细菌病原体在宿主定植和感染过程中会经历显著的适应性变化，以应对选择压力。过去几十年的研究表明，在宿主适应过程中可以发现许多一般的进化过程，包括谱系的遗传多样化、克隆继替事件、趋同进化和平衡的适应权衡。在某些情况下，错配修复或校对缺陷导致的高突变率会加速进化，而活跃的移动遗传元件或噬菌体可能会促进基因组可塑性。宿主免疫反应为指导适应的适应度景观提供了另一个关键组成部分，在这个水平上对病原体的选择可能导致免疫逃逸和慢性感染的建立。本综述总结了该领域的最新进展，特别关注感染背景下细菌基因组可塑性的不同形式，并考虑了宿主适应性变化的临床后果。
