Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Arch Virol. 2023 Oct 13;168(11):271. doi: 10.1007/s00705-023-05897-1.
Severe fever with thrombocytopenia syndrome virus (SFTSV) has been reported in many countries in Southeast Asia, which expands the original geographic range of China, Korea, and Japan. Here, we report the complete genome sequences of two Thai SFTSV strains previously identified in patients with undifferentiated febrile illness in 2020. Phylogenetically, both clustered with SFTSV genotype B strains and were most closely related to those previously reported in central China (≥99.0% nucleotide sequence identity) in the L, M, and S gene segments. Nine amino acid residues encoded by one or more Thai SFTSV genomes differed from those found in global strains. Interestingly, the observed differences in numerous residues between the Thai strains suggest possible separate introductions of different variants into the region.
严重发热伴血小板减少综合征病毒（SFTSV）已在东南亚多个国家报告，这扩大了中国、韩国和日本的原有地理范围。在这里，我们报告了 2020 年在患有未分化发热疾病的患者中先前鉴定的两株泰国 SFTSV 株的完整基因组序列。系统进化分析表明，这两株病毒均与 SFTSV 基因型 B 株聚类，与中国中部地区先前报告的病毒（L、M 和 S 基因片段的核苷酸序列同一性≥99.0%）最为密切相关。一个或多个泰国 SFTSV 基因组编码的 9 个氨基酸残基与在全球株中发现的不同。有趣的是，泰国株中观察到的许多残基差异表明，该地区可能有不同变体的单独引入。
