The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road,Shangcheng District Hangzhou, 310009, Hangzhou, Zhejiang, China.
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
BMC Urol. 2023 Oct 14;23(1):163. doi: 10.1186/s12894-023-01335-1.
There are no clear conclusions as to whether heart failure (HF) and coronary heart disease (CAD) increase the risk of erectile dysfunction (ED).In our study, we used Mendelian randomization (MR) analysis to discover a causal relationship between HF, CAD and ED.
Single nucleotide polymorphisms (SNPs) associated with HF, CAD and ED were obtained from the MRC IEU Open Genome-Wide Association Study (GWAS) database.After a series of screenings, the remaining SNPs were selected as instrumental variables (IVs) for HF and CAD for MR analysis to assess the relationship between genetically predicted HF or CAD and the pathogenesis of ED.Among them, we used the random-effects inverse variance weighted (IVW) method as the primary analysis method.Finally, Cochran's q-test, funnel plots, MR-Egger regression, Leave-one-out method and MR-PRESSO were used for sensitivity analysis.
In the IVW method, there was no significant causal relationship between genetically predicted HF and CAD and the incidence of ED.(HF: OR = 1.17, 95% CI 0.99-1.39; p = 0.074;CAD: OR = 1.08, 95% CI 0.99-1.17, p = 0.068)。The results of sensitivity analyses supported our conclusion that no horizontal pleiotropism was found.
This study did not find a causal relationship between HF or CAD and ED in European populations, which requires further in-depth research.
心力衰竭（HF）和冠心病（CAD）是否会增加勃起功能障碍（ED）的风险尚无明确结论。在本研究中，我们使用孟德尔随机化（MR）分析来发现 HF、CAD 和 ED 之间的因果关系。
从 MRC IEU 开放全基因组关联研究（GWAS）数据库中获得与 HF、CAD 和 ED 相关的单核苷酸多态性（SNP）。经过一系列筛选，选择剩余的 SNP 作为 HF 和 CAD 的工具变量（IV）进行 MR 分析，以评估遗传预测的 HF 或 CAD 与 ED 发病机制之间的关系。其中，我们使用随机效应逆方差加权（IVW）法作为主要分析方法。最后，使用 Cochran's q 检验、漏斗图、MR-Egger 回归、Leave-one-out 法和 MR-PRESSO 进行敏感性分析。
在 IVW 方法中，遗传预测的 HF 和 CAD 与 ED 的发病之间没有显著的因果关系。（HF：OR=1.17，95%CI 0.99-1.39；p=0.074；CAD：OR=1.08，95%CI 0.99-1.17，p=0.068）。敏感性分析的结果支持我们的结论，即没有发现水平遗传异质性。
本研究在欧洲人群中未发现 HF 或 CAD 与 ED 之间存在因果关系，这需要进一步深入研究。
