心力衰竭和冠心病对勃起功能障碍的影响：两样本孟德尔随机研究。

Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample mendelian randomization study.

机构信息

The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road,Shangcheng District Hangzhou, 310009, Hangzhou, Zhejiang, China.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

BMC Urol. 2023 Oct 14;23(1):163. doi: 10.1186/s12894-023-01335-1.

DOI:10.1186/s12894-023-01335-1

PMID:37833702

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10576338/

Abstract

BACKGROUND AND AIMS

There are no clear conclusions as to whether heart failure (HF) and coronary heart disease (CAD) increase the risk of erectile dysfunction (ED).In our study, we used Mendelian randomization (MR) analysis to discover a causal relationship between HF, CAD and ED.

METHODS

Single nucleotide polymorphisms (SNPs) associated with HF, CAD and ED were obtained from the MRC IEU Open Genome-Wide Association Study (GWAS) database.After a series of screenings, the remaining SNPs were selected as instrumental variables (IVs) for HF and CAD for MR analysis to assess the relationship between genetically predicted HF or CAD and the pathogenesis of ED.Among them, we used the random-effects inverse variance weighted (IVW) method as the primary analysis method.Finally, Cochran's q-test, funnel plots, MR-Egger regression, Leave-one-out method and MR-PRESSO were used for sensitivity analysis.

RESULTS

In the IVW method, there was no significant causal relationship between genetically predicted HF and CAD and the incidence of ED.(HF: OR = 1.17, 95% CI 0.99-1.39; p = 0.074;CAD: OR = 1.08, 95% CI 0.99-1.17, p = 0.068)。The results of sensitivity analyses supported our conclusion that no horizontal pleiotropism was found.

CONCLUSION

This study did not find a causal relationship between HF or CAD and ED in European populations, which requires further in-depth research.

摘要

背景与目的

心力衰竭（HF）和冠心病（CAD）是否会增加勃起功能障碍（ED）的风险尚无明确结论。在本研究中，我们使用孟德尔随机化（MR）分析来发现 HF、CAD 和 ED 之间的因果关系。

方法

从 MRC IEU 开放全基因组关联研究（GWAS）数据库中获得与 HF、CAD 和 ED 相关的单核苷酸多态性（SNP）。经过一系列筛选，选择剩余的 SNP 作为 HF 和 CAD 的工具变量（IV）进行 MR 分析，以评估遗传预测的 HF 或 CAD 与 ED 发病机制之间的关系。其中，我们使用随机效应逆方差加权（IVW）法作为主要分析方法。最后，使用 Cochran's q 检验、漏斗图、MR-Egger 回归、Leave-one-out 法和 MR-PRESSO 进行敏感性分析。