Shaanxi Centre of Stem Cells Engineering & Technology, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China.
Int J Mol Sci. 2023 Sep 23;24(19):14484. doi: 10.3390/ijms241914484.
Fractures are the most common large organ trauma in humans. The initial inflammatory response promotes bone healing during the initial post-fracture phase, but chronic and persistent inflammation due to infection or other factors does not contribute to the healing process. The precise mechanisms by which immune cells and their cytokines are regulated in bone healing remain unclear. The use of mesenchymal stem cells (MSCs) for cellular therapy of bone injuries is a novel clinical treatment approach. Bone progenitor MSCs not only differentiate into bone, but also interact with the immune system to promote the healing process. We review in vitro and in vivo studies on the role of the immune system and bone marrow MSCs in bone healing and their interactions. A deeper understanding of this paradigm may provide clues to potential therapeutic targets in the healing process, thereby improving the reliability and safety of clinical applications of MSCs to promote bone healing.
骨折是人类中最常见的大型器官创伤。初始炎症反应在骨折后初始阶段促进骨愈合，但感染或其他因素引起的慢性和持续炎症对愈合过程没有帮助。免疫细胞及其细胞因子在骨愈合中的调节的精确机制仍不清楚。使用间充质干细胞（MSCs）进行骨损伤的细胞治疗是一种新的临床治疗方法。骨祖细胞 MSC 不仅分化为骨，而且与免疫系统相互作用以促进愈合过程。我们综述了关于免疫系统和骨髓 MSC 在骨愈合及其相互作用中的作用的体外和体内研究。对这一范例的更深入理解可能为愈合过程中的潜在治疗靶点提供线索，从而提高 MSC 促进骨愈合的临床应用的可靠性和安全性。
