Wang Jing, Xu Shenghao, Chen Bo, Qin Yanguo
Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin, China.
Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, Jilin University, Changchun, Jilin, China.
Front Immunol. 2025 Apr 10;16:1567640. doi: 10.3389/fimmu.2025.1567640. eCollection 2025.
Orthopedic diseases pose significant challenges to public health due to their high prevalence, debilitating effects, and limited treatment options. Additionally, orthopedic tumors, such as osteosarcoma, chondrosarcoma, and Ewing sarcoma, further complicate the treatment landscape. Current therapies, including pharmacological treatments and joint replacement, address symptoms but fail to promote true tissue regeneration. Cell-based therapies, which have shown successful clinical results in cancers and other diseases, have emerged as a promising solution to repair damaged tissues and restore function in orthopedic diseases and tumors. This review discusses the advances and potential application of cell therapy for orthopedic diseases, with a particular focus on osteoarthritis, bone fractures, cartilage degeneration, and the treatment of orthopedic tumors. We explore the potential of mesenchymal stromal cells (MSCs), chondrocyte transplantation, engineered immune cells and induced pluripotent stem cells to enhance tissue regeneration by modulating the immune response and addressing inflammation. Ultimately, the integration of cutting-edge cell therapy, immune modulation, and molecular targeting strategies could revolutionize the treatment of orthopedic diseases and tumors, providing hope for patients seeking long-term solutions to debilitating conditions.
骨科疾病因其高发病率、使人衰弱的影响和有限的治疗选择，对公众健康构成了重大挑战。此外，骨肉瘤、软骨肉瘤和尤因肉瘤等骨科肿瘤，使治疗情况更加复杂。目前的治疗方法，包括药物治疗和关节置换，只能缓解症状，却无法促进真正的组织再生。基于细胞的疗法在癌症和其他疾病的治疗中已取得成功的临床效果，它已成为修复受损组织并恢复骨科疾病和肿瘤功能的一种有前景的解决方案。这篇综述讨论了细胞疗法在骨科疾病治疗方面的进展和潜在应用，特别关注骨关节炎、骨折、软骨退变以及骨科肿瘤的治疗。我们探讨了间充质基质细胞（MSC）、软骨细胞移植、工程免疫细胞和诱导多能干细胞通过调节免疫反应和解决炎症来增强组织再生的潜力。最终，前沿细胞疗法、免疫调节和分子靶向策略的整合可能会彻底改变骨科疾病和肿瘤的治疗方式，为寻求长期解决衰弱病症方案的患者带来希望。
