State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Department of Oral Medicine, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Int J Mol Sci. 2023 Sep 26;24(19):14532. doi: 10.3390/ijms241914532.
Oral squamous cell carcinoma (OSCC) poses a significant obstacle to the worldwide healthcare system. Discovering efficient and non-toxic medications is crucial for managing OSCC. Nuciferine, an alkaloid with an aromatic ring, is present in the leaves of . It has been proven to play a role in multiple biological processes, including the inhibition of inflammation, regulation of the immune system, formation of osteoclasts, and suppression of tumors. Despite the demonstrated inhibitory effects of nuciferine on different types of cancer, there is still a need for further investigation into the therapeutic effects and potential mechanisms of nuciferine in OSCC. Through a series of in vitro experiments, it was confirmed that nuciferine hindered the growth, movement, and infiltration, while enhancing the programmed cell death of OSCC cells. Furthermore, the administration of nuciferine significantly suppressed the signal transducer and activator of transcription 3 (STAT3) signaling pathway in comparison to other signaling pathways. Moreover, the activation of the STAT3 signaling pathway by colivelin resulted in the reversal of nuciferine-suppressed OSCC behaviors. In vivo, we also showed the anti-OSCC impact of nuciferine using the cell-based xenograft (CDX) model in nude mice. Nonetheless, colivelin diminished the tumor-inhibiting impact of nuciferine, suggesting that nuciferine might partially impede the advancement of OSCC by suppressing the STAT3 signaling pathway. Overall, this research could offer a fresh alternative for the pharmaceutical management of OSCC.
口腔鳞状细胞癌（OSCC）对全球医疗保健系统构成重大挑战。发现高效且无毒的药物对于 OSCC 的治疗至关重要。Nuciferine 是一种具有芳环的生物碱，存在于. 的叶子中。它已被证明在多种生物学过程中发挥作用，包括抑制炎症、调节免疫系统、形成破骨细胞和抑制肿瘤。尽管 nuciferine 已被证明对不同类型的癌症具有抑制作用，但仍需要进一步研究 nuciferine 在 OSCC 中的治疗效果和潜在机制。通过一系列体外实验，证实 nuciferine 可抑制 OSCC 细胞的生长、运动和浸润，并促进其程序性细胞死亡。此外，与其他信号通路相比，nuciferine 对信号转导和转录激活因子 3（STAT3）信号通路的抑制作用更为显著。此外，colivelin 激活 STAT3 信号通路可逆转 nuciferine 抑制的 OSCC 行为。在体内，我们还使用裸鼠细胞异种移植（CDX）模型证实了 nuciferine 的抗 OSCC 作用。然而，colivelin 减弱了 nuciferine 的肿瘤抑制作用，表明 nuciferine 可能通过抑制 STAT3 信号通路部分阻碍 OSCC 的进展。总的来说，这项研究为 OSCC 的药物治疗提供了一种新的选择。
