Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Social Determinants of Health Research Center, Mashhad University o Medical Sciences, Mashhad, Iran.
Photodiagnosis Photodyn Ther. 2023 Mar;41:103248. doi: 10.1016/j.pdpdt.2022.103248. Epub 2022 Dec 21.
Early detection of OSCC is a crucial step towards improving OSCC prognosis. In recent years, novel diagnostic aids such as light-based detection systems have been introduced for early diagnosis. VELscope is one such light-based device which is used to examine tissue fluorescence. Based on different studies, VELscope has a sensitivity of 90% in the diagnosis of oral premalignant and malignant lesions. Tumor depth of invasion and invasive front have recently been proposed as influential factors in OSCC prognosis. Therefore, the aim of this study was to assess the relationship between tissue color seen through this device and tumor depth of invasion.
METHODS & MATERIALS: 20 histopathologically approved OSCCs were included in this study. Conventional oral examination was carried out followed by an assessment of the lesion using VELscope. The H&E slides prepared following the final OSCC surgeries were then examined by an oral pathologist to assess tumor depth of invasion (interpreted as low-risk/high-risk), invasivefront (low-risk/high-risk) and perivascular and perineural invasions. Data was transferred to SPSS 16 software. The association between color changes and histopathological factors was analyzed using the fisher's exact and chi-square tests.
The mean age of the patients was 51/5+/-16/74, 60% of which were men. Most lesions were exophytic and the most common color seen during VELscope examination was red. 55% and 50% of the OSCCs showed high-risk tumor depths and high-risk invasive fronts respectively. Perivascular and perineural invasion was seen in 55% and 35% of the samples respectively. Statistical analysis showed that 72/2% of the lesions with high tumor depths and 70% with high-risk invasive fronts were seen as red, although these associations were not significant (P>0/05). Tumor depth was significantly correlated with invasive front (P<0/05).
There was no significant relationship between the type of color seen through VELscope and tumor depth of invasion, however most cases with high-risk depth of invasions were red.
口腔鳞状细胞癌（OSCC）的早期检测是改善其预后的关键步骤。近年来，已经引入了新型诊断辅助工具，例如基于光的检测系统，用于早期诊断。VELscope 就是这样一种基于光的设备，用于检查组织荧光。根据不同的研究，VELscope 在诊断口腔癌前病变和恶性病变方面的灵敏度为 90％。肿瘤浸润深度和侵袭前沿最近被提出是影响 OSCC 预后的因素。因此，本研究旨在评估通过该设备观察到的组织颜色与肿瘤浸润深度之间的关系。
本研究纳入了 20 例经组织病理学证实的 OSCC 患者。进行了常规口腔检查，然后使用 VELscope 评估病变。随后，由口腔病理学家检查制备的 H&E 幻灯片，以评估肿瘤浸润深度（低危/高危）、侵袭前沿（低危/高危）以及血管周围和神经周围浸润。将数据转移到 SPSS 16 软件中。使用 Fisher 精确检验和卡方检验分析颜色变化与组织病理学因素之间的关联。
患者的平均年龄为 51/5+/-16/74 岁，其中 60％为男性。大多数病变为外生性，在 VELscope 检查中最常见的颜色是红色。55％和 50％的 OSCC 分别显示高危肿瘤深度和高危侵袭前沿。在 55％和 35％的样本中分别观察到血管周围和神经周围浸润。统计分析表明，72/2％的高肿瘤深度病变和 70％的高侵袭前沿病变呈红色，尽管这些关联没有统计学意义（P＞0/05）。肿瘤深度与侵袭前沿显著相关（P＜0/05）。
通过 VELscope 观察到的颜色类型与肿瘤浸润深度之间没有显著关系，但是大多数高危深度浸润的病例呈红色。
