Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmacol Res. 2022 Jan;175:106002. doi: 10.1016/j.phrs.2021.106002. Epub 2021 Nov 24.
Obesity, is an increasingly global public health problem associated complications. However, the proven anti-obesity agents are inefficient with adverse side effects; hence attention is being paid to novel drugs from natural resources to manage obesity and obesity-related diseases. Nuciferine (NF) is a high-quality aporphine alkaloid present in lotus leaf. Unlike the chemical drugs, NF elicits anti-obesity, anti-dyslipidemia, anti-hyperglycemic, anti-hypouricemic, anti-inflammatory, and anti-tumor effects, and affinity to neural receptors, and protection against obesity-related diseases. The underlying mechanism of NF includes the regulation of targeted molecules and pathways related to metabolism, inflammation, and cancer and modulation of Ca flux, gut microbiota, and ferroptosis. Besides, the clinical application, availability, pharmacokinetics, pharmaceutics, and security of NF have been established, highlighting the potential of developing NF as an anti-obesity agent. Therefore, this review provides a comprehensive summarization, which sheds light on future research in NF.
肥胖是一个日益严重的全球性公共卫生问题，与之相关的并发症也层出不穷。然而，现有的抗肥胖药物疗效不理想，且存在不良反应；因此，人们开始关注从天然资源中寻找新型药物来治疗肥胖和肥胖相关疾病。荷叶中的高含量阿朴啡类生物碱——荷叶碱（NF）就是一种这样的药物。与化学药物不同，NF 具有抗肥胖、抗血脂异常、抗高血糖、抗高尿酸血症、抗炎和抗肿瘤作用，对神经受体具有亲和力，并能预防肥胖相关疾病。NF 的作用机制包括调节与代谢、炎症和癌症相关的靶向分子和通路，以及调节钙流、肠道微生物群和铁死亡。此外，NF 的临床应用、可用性、药代动力学、药剂学和安全性已得到确立，这突显了将 NF 开发为抗肥胖药物的潜力。因此，本综述提供了一个全面的总结，为 NF 的未来研究提供了思路。
