• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

作者信息

Roberts M S, Rowland M

出版信息

J Pharmacokinet Biopharm. 1986 Jun;14(3):289-308. doi: 10.1007/BF01106708.

DOI:10.1007/BF01106708
PMID:3783448
Abstract

A dispersion model of hepatic elimination is presented to describe metabolite formation and elimination kinetics within the liver, consistent with the known physiology and biochemistry of this organ. The model is based on the spread in residence times of blood flowing through the liver. This dispersion model is shown to be more consistent with transient and steady-state data obtained after the single passage of phenacetin and acetaminophen through the liver (both normal and retrograde perfusions) than other models of hepatic elimination. The dispersion model is suitable for the evaluation of enzyme heterogeneity using experimentally obtained metabolite data.

摘要

相似文献

1
A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.
J Pharmacokinet Biopharm. 1986 Jun;14(3):289-308. doi: 10.1007/BF01106708.
2
The effect of intercellular distribution of drug-metabolizing enzymes on the kinetics of stable metabolite formation and elimination by liver: first-pass effects.药物代谢酶的细胞间分布对肝脏中稳定代谢物形成和消除动力学的影响：首过效应。
Drug Metab Rev. 1983;14(1):61-76. doi: 10.3109/03602538308991381.
3
Metabolite kinetics: formation of acetaminophen from deuterated and nondeuterated phenacetin and acetanilide on acetaminophen sulfation kinetics in the perfused rat liver preparation.代谢物动力学：在灌注大鼠肝脏制剂中，由氘代和非氘代非那西丁及乙酰苯胺生成对乙酰氨基酚对其硫酸化动力学的影响。
J Pharmacol Exp Ther. 1982 Jul;222(1):14-9.
4
Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats.逆行灌注法探究大鼠肝脏药物代谢酶的异质性分布
J Pharmacol Exp Ther. 1981 Feb;216(2):339-46.
5
A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.肝脏消除的弥散模型：2. 稳态考量——肝血流量、血液内结合以及肝细胞酶活性的影响
J Pharmacokinet Biopharm. 1986 Jun;14(3):261-88. doi: 10.1007/BF01106707.
6
Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin.灌注大鼠肝脏制剂中代谢物形成与消除的动力学：预先形成的对乙酰氨基酚与由非那西丁形成的对乙酰氨基酚在消除方面的差异。
J Pharmacol Exp Ther. 1978 Oct;207(1):178-94.
7
Sequential first-pass elimination of a metabolite derived from a precursor.
J Pharmacokinet Biopharm. 1979 Jun;7(3):275-90. doi: 10.1007/BF01060018.
8
A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.肝脏消除的弥散模型：1. 模型的建立及大剂量注射的考量
J Pharmacokinet Biopharm. 1986 Jun;14(3):227-60. doi: 10.1007/BF01106706.
9
Metabolite pharmacokinetics: methods for simultaneous estimates of elimination rate constants of a drug and its metabolite. A commentary.代谢物药代动力学：同时估算药物及其代谢物消除速率常数的方法。一篇评论
Drug Metab Dispos. 1980 Jan-Feb;8(1):39-43.
10
Formation of chemically reactive metabolites of phenacetin and acetaminophen.
Adv Exp Med Biol. 1981;136 Pt B:931-50.

引用本文的文献

1
Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs.选择用于准确预测白蛋白结合敏感药物肝脏清除率的最佳代谢模型。
Pharmaceuticals (Basel). 2025 Jul 1;18(7):991. doi: 10.3390/ph18070991.
2
Predicting Clearance with Simple and Permeability-Limited Physiologically Based Pharmacokinetic Frameworks: Comparison of Well-Stirred, Dispersion, and Parallel-Tube Liver Models.运用简单且具有通透性限制的生理药代动力学框架预测清除率：搅拌池、弥散和并行管肝脏模型的比较。
Drug Metab Dispos. 2024 Sep 16;52(10):1060-1072. doi: 10.1124/dmd.124.001782.
3
The Application of a Physiologically Based Toxicokinetic Model in Health Risk Assessment.

本文引用的文献

1
A linear method for determining liver sinusoidal and extravascular volumes.一种用于确定肝窦和血管外容积的线性方法。
Am J Physiol. 1963 Apr;204:626-40. doi: 10.1152/ajplegacy.1963.204.4.626.
2
Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats.逆行灌注法探究大鼠肝脏药物代谢酶的异质性分布
J Pharmacol Exp Ther. 1981 Feb;216(2):339-46.
3
On the location of cellular functions in perfused organs.关于灌注器官中细胞功能的位置
基于生理学的毒代动力学模型在健康风险评估中的应用。
Toxics. 2023 Oct 21;11(10):874. doi: 10.3390/toxics11100874.
4
Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data.通过体外数据预测体内II期葡萄糖醛酸化代谢的挑战与机遇
Curr Pharmacol Rep. 2016 Dec;2(6):326-338. doi: 10.1007/s40495-016-0076-8. Epub 2016 Nov 8.
5
A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model.一种基于生理的肝脏药物消除血流网络模型I：规则格状小叶模型。
Theor Biol Med Model. 2013 Sep 5;10:52. doi: 10.1186/1742-4682-10-52.
6
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.肝细胞坏死、纤维化和微粒体活性决定了右心衰竭性肝损伤患者体内碱性药物的肝药代动力学。
Pharm Res. 2012 Jun;29(6):1658-69. doi: 10.1007/s11095-012-0690-z.
7
Drug structure-transport relationships.药物结构-转运关系。
J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):541-73. doi: 10.1007/s10928-010-9174-0. Epub 2010 Nov 24.
8
Founding figures of pharmacokinetics: tribute to Malcolm Rowland.
J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):525-7. doi: 10.1007/s10928-010-9178-9.
9
Modeling kinetics of subcellular disposition of chemicals.化学物质亚细胞分布动力学建模。
Chem Rev. 2009 May;109(5):1793-899. doi: 10.1021/cr030440j.
10
Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model.用扩展对流扩散模型对肝脏消除和器官分布动力学进行建模。
J Pharmacokinet Biopharm. 1999 Aug;27(4):343-82. doi: 10.1023/a:1020992421184.
J Theor Biol. 1980 Feb 7;82(3):347-51. doi: 10.1016/0022-5193(80)90241-6.
4
Functional zones in rat liver: the degree of overlap.大鼠肝脏中的功能区：重叠程度
J Theor Biol. 1981 Mar 21;89(2):303-19. doi: 10.1016/0022-5193(81)90313-1.
5
Functional implications of liver cell heterogeneity.肝细胞异质性的功能意义。
Gastroenterology. 1981 Feb;80(2):393-403.
6
Liver blood flow. II. Effects of drugs and hormones on liver blood flow.肝脏血流。二、药物和激素对肝脏血流的影响。
Gastroenterology. 1981 Aug;81(2):356-75.
7
Clearance concepts in pharmacokinetics.药代动力学中的清除概念。
J Pharmacokinet Biopharm. 1973 Apr;1(2):123-36. doi: 10.1007/BF01059626.
8
Hepatic elimination--dispersion model.
J Pharm Sci. 1985 May;74(5):585-7. doi: 10.1002/jps.2600740522.
9
A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.肝脏消除的弥散模型：2. 稳态考量——肝血流量、血液内结合以及肝细胞酶活性的影响
J Pharmacokinet Biopharm. 1986 Jun;14(3):261-88. doi: 10.1007/BF01106707.
10
A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.肝脏消除的弥散模型：1. 模型的建立及大剂量注射的考量
J Pharmacokinet Biopharm. 1986 Jun;14(3):227-60. doi: 10.1007/BF01106706.