Lee Juhun, Lee Hyun Jung
Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.
J Clin Med. 2023 Sep 24;12(19):6155. doi: 10.3390/jcm12196155.
The high-risk human papillomavirus (HR-HPV) has been known as the most important carcinogen in uterine cervical carcinoma. However, there is limited evidence of the malignant potential of these concurrent multiple infections. This study included women who had undergone cervical conization. They underwent an HPV test by cervical swab within 12 months before the surgery. They were divided into two groups: one with a single infection with HR-HPV16 and the other with concurrent multiple infections with HR-HPVs, including genotype 16. Pathologic examination classified cases as CIS+ to assess and compare the malignant potential in both groups, including carcinoma in situ (CIS) and invasive carcinoma. Of the 220 patients infected with HR-HPV16, the single infection group consisted of 120 patients (54.5%), whereas the concurrent multiple infections consisted of 100 (45.5%) patients. The rates of HSIL were significantly higher in the concurrent multiple infection group. However, the odds ratio for CIS+ did not show a significant difference between both groups (1.417, 95% CI = 0.831-2.414, = 0.200). The malignant potential was not significantly different between concurrent multiple infections with HR-HPVs, including 16, and a single infection with 16 in Korean women.
高危型人乳头瘤病毒（HR-HPV）被认为是子宫颈癌最重要的致癌物。然而，关于这些同时发生的多重感染的恶性潜能的证据有限。本研究纳入了接受宫颈锥切术的女性。她们在手术前12个月内通过宫颈拭子进行了HPV检测。她们被分为两组：一组为单一感染HR-HPV16，另一组为同时发生包括16型在内的HR-HPV多重感染。病理检查将病例分类为CIS+，以评估和比较两组的恶性潜能，包括原位癌（CIS）和浸润癌。在220例感染HR-HPV16的患者中，单一感染组有120例（54.5%），而同时发生多重感染的有100例（45.5%）。同时发生多重感染组的HSIL发生率显著更高。然而，两组之间CIS+的优势比没有显著差异（1.417，95%CI = 0.831-2.414，P = 0.200）。在韩国女性中，包括16型在内的HR-HPV多重感染与单一感染16型之间的恶性潜能没有显著差异。
