二甲双胍在头颈癌中的预防和治疗作用：简要综述
Preventive and Therapeutic Effect of Metformin in Head and Neck Cancer: A Concise Review.
作者信息
Bouland Cyril, Vanden Eynden Xavier, Lalmand Martin, Buset Thibaut, Yanni Antoine, Javadian Rokneddine, Rodriguez Alexandra, Loeb Isabelle, Lechien Jérôme R, Journe Fabrice, Saussez Sven, Dequanter Didier
机构信息
Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium.
Department of Otorhinolaryngology-Head and Neck Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium.
出版信息
J Clin Med. 2023 Sep 25;12(19):6195. doi: 10.3390/jcm12196195.
BACKGROUND
Head and neck cancer (HNC) is a complex affection. Nowadays, conventional treatments are associated with many side effects, reducing the patient's quality of life. Recent studies suggest that metformin, a first-line treatment for diabetes, could decrease cancer incidence and improve cancer-related survival rates.
METHODS
This systematic review summarizes important data from studies evaluating metformin's contribution to preventing and treating HNC.
RESULTS
The results suggest a protective effect of metformin in HNC. However, no consensus has been found on its therapeutic effects. Metformin seems to confer an improved cancer-related survival rate in a diabetic population, but compared to a non-diabetic population, the review could not identify any advantages. Nevertheless, no studies presented a negative impact.
CONCLUSION
In conclusion, the results of this systematic review suggest that HNC patients may benefit from metformin. Indeed, it would reduce the HNC incidence. However, more studies are required to evaluate the effect on cancer-related survival rates.
背景
头颈癌（HNC）是一种复杂的疾病。如今，传统治疗方法伴随着许多副作用，降低了患者的生活质量。最近的研究表明，二甲双胍作为糖尿病的一线治疗药物，可能会降低癌症发病率并提高癌症相关生存率。
方法
本系统评价总结了评估二甲双胍对预防和治疗头颈癌贡献的研究中的重要数据。
结果
结果表明二甲双胍对头颈癌有保护作用。然而，关于其治疗效果尚未达成共识。二甲双胍似乎能提高糖尿病患者的癌症相关生存率，但与非糖尿病患者相比，本评价未发现任何优势。不过，也没有研究表明有负面影响。
结论
总之，本系统评价的结果表明头颈癌患者可能从二甲双胍中获益。确实，它会降低头颈癌发病率。然而，需要更多研究来评估其对癌症相关生存率的影响。
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