Kadioglu Nezaket, Kahyaoğlu İnci, Kaplanoğlu İskender, Dilbaz Serdar, Engin Üstün Yaprak
Department of Obstetrics and Gynecology, University of Yuksek Ihtisas, Ankara 06530, Turkey.
Department of Assisted Reproductive Technology, Etlik City Hospital, University of Health Sciences, Ankara 06620, Turkey.
J Clin Med. 2023 Sep 27;12(19):6236. doi: 10.3390/jcm12196236.
We aimed to investigate the clinical results following poor-quality embryo transfer and the parameters to foresee the prognosis. In this study, 2123 cycles that had day 3 and day 5 single-fresh embryo with poor-quality embryo transfers and good-quality embryo transfers were compared. The cycles according to transfer day were evaluated by conducting a subgroup analysis. The correlation between all the obtained demographic characteristics, controlled ovarian stimulation parameters, and cycle results were analysed. Clinical pregnancy was established in 53 patients that underwent transfer in the poor-quality embryo group (14.9%). Of these patients, 36 had live birth (live birth rate per clinical pregnancy 67.9%). In cleavage-stage embryos, live birth rates per clinical pregnancy were higher in poor-quality blastocyst transfer. When analysing the factors affecting live births in the poor-quality embryo group, as the total gonadotropin dose increases, the probability of live birth decreases, as in the probability of hCG positivity. In conclusion, although the probability of pregnancy is low, when clinical pregnancy is established, there is a high chance of having a live birth after poor-quality embryo transfers. This could be regarded as an acceptable option in cycles when only poor-quality embryos are available.
我们旨在研究低质量胚胎移植后的临床结果以及预测预后的参数。在本研究中，对2123个周期进行了比较，这些周期包括第3天和第5天单新鲜胚胎移植，其中既有低质量胚胎移植，也有高质量胚胎移植。根据移植日对周期进行亚组分析评估。分析了所有获得的人口统计学特征、控制性卵巢刺激参数与周期结果之间的相关性。低质量胚胎组中有53例患者移植后临床妊娠（14.9%）。在这些患者中，36例活产（每例临床妊娠的活产率为67.9%）。在卵裂期胚胎中，低质量囊胚移植的每例临床妊娠活产率更高。在分析低质量胚胎组中影响活产的因素时，与hCG阳性概率一样，随着总促性腺激素剂量增加，活产概率降低。总之，尽管妊娠概率较低，但低质量胚胎移植后一旦临床妊娠，活产几率较高。在仅有低质量胚胎可用的周期中，这可被视为一个可接受的选择。
