Cebola Pedro, Caroça Cristina, Donato Helena, Campos Ana, Dias Sara Simões, Paço João, Manso Cristina
Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.
CUF Tejo Hospital, 1300-352 Lisboa, Portugal.
J Clin Med. 2023 Oct 1;12(19):6328. doi: 10.3390/jcm12196328.
Obstructive sleep apnea is a sleep disorder with a high prevalence in the world population. The mandibular advancement device is one of the options for treating obstructive sleep apnea. Neck computed tomography and drug-induced sleep endoscopy are complementary diagnostic tests that may help predict the effectiveness of mandibular advancement devices. This study aims to analyze the best method for predicting the effectiveness of mandibular advancement devices in the therapeutic approach to obstructive sleep apnea. PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection databases will be comprehensively searched. We will include randomized clinical trials, non-randomized prospective or retrospective clinical studies, case controls, cohort studies, and case series. Two authors will independently conduct data extraction and assess the literature quality of the studies. The analysis of the included literature will be conducted by Revman 5.3 software. The outcomes that will be analyzed are craniofacial characteristics, cephalometric assessments, site and type of obstruction of the upper airway, mean values of the apnea-hypopnea index, and SaO verified in the initial and follow-up polysomnography. This study will provide reliable, evidence-based support for the clinical application of mandibular advancement devices for obstructive sleep apnea.
阻塞性睡眠呼吸暂停是一种在世界人口中患病率很高的睡眠障碍。下颌前移装置是治疗阻塞性睡眠呼吸暂停的选择之一。颈部计算机断层扫描和药物诱导睡眠内镜检查是辅助诊断测试，可能有助于预测下颌前移装置的疗效。本研究旨在分析在阻塞性睡眠呼吸暂停治疗方法中预测下颌前移装置疗效的最佳方法。将全面检索PubMed、Embase、Cochrane对照试验中央注册库（CENTRAL）和Web of Science核心合集数据库。我们将纳入随机临床试验、非随机前瞻性或回顾性临床研究、病例对照研究、队列研究和病例系列。两名作者将独立进行数据提取并评估研究的文献质量。将使用Revman 5.3软件对纳入文献进行分析。将分析的结果包括颅面特征、头影测量评估、上气道阻塞部位和类型、呼吸暂停低通气指数的平均值以及在初始和随访多导睡眠图中验证的SaO。本研究将为下颌前移装置在阻塞性睡眠呼吸暂停临床应用中提供可靠的循证支持。
