Meisinger Christa, Kirchberger Inge, Raake Philip, Linseisen Jakob, Schmitz Timo
Epidemiology, Medical Faculty, University of Augsburg, 86156 Augsburg, Germany.
Department of Cardiology, Respiratory Medicine and Intensive Care, University Hospital Augsburg, 86156 Augsburg, Germany.
J Clin Med. 2023 Oct 3;12(19):6349. doi: 10.3390/jcm12196349.
The interplay between fatigue and depression and their association with health-related quality of life (HRQoL) after acute myocardial infarction (AMI) has received little attention during the COVID-19 pandemic. Therefore, this study evaluated the frequency of fatigue and depression in post-AMI patients during the COVID-19 pandemic and investigated the cross-sectional associations between fatigue, depression and HRQoL.
The analysis was based on population-based Myocardial Infarction Registry Augsburg data. All survivors of AMI between 1 June 2020 and 15 September 2021 were included ( 882) and received a postal questionnaire containing questions about fatigue (Fatigue Assessment Scale), depression (Patient Health Questionnaire), and HRQoL (MacNew Heart Disease HRQoL questionnaire) on 17 November 2021. The questionnaire was returned by 592 patients (67.1%), and 574 participants could be included in the analysis. Multivariable linear regression models were performed to investigate the associations between fatigue and depression (both exposures) and HRQoL (outcome).
Altogether, 273 (47.6%) participants met the criteria for the presence of fatigue, about 16% showed signs of moderate to severe depression. Both fatigue and depression were significantly associated with a decreased HRQoL (total score and emotional, social, and physical subscales; all -values < 0.0001). In particular, a combined occurrence of fatigue and depression was associated with a significantly reduced HRQoL.
It seems necessary to screen post-MI patients for the presence of fatigue and depression in clinical practice on a routine basis to provide them with adequate support and treatment and thus also to improve their HRQoL.
在新冠疫情期间，急性心肌梗死（AMI）后疲劳与抑郁之间的相互作用及其与健康相关生活质量（HRQoL）的关联很少受到关注。因此，本研究评估了新冠疫情期间AMI后患者疲劳和抑郁的发生率，并调查了疲劳、抑郁与HRQoL之间的横断面关联。
分析基于奥格斯堡基于人群的心肌梗死登记数据。纳入了2020年6月1日至2021年9月15日期间AMI的所有幸存者（882例），并于2021年11月17日向他们发送了一份邮政问卷，其中包含有关疲劳（疲劳评估量表）、抑郁（患者健康问卷）和HRQoL（MacNew心脏病HRQoL问卷）的问题。592名患者（67.1%）返回了问卷，574名参与者可纳入分析。进行多变量线性回归模型以研究疲劳和抑郁（均为暴露因素）与HRQoL（结果）之间的关联。
共有273名（47.6%）参与者符合存在疲劳的标准，约16%表现出中度至重度抑郁的迹象。疲劳和抑郁均与HRQoL降低显著相关（总分以及情感、社会和身体子量表；所有P值<0.0001）。特别是，疲劳和抑郁同时出现与HRQoL显著降低相关。
在临床实践中，似乎有必要对AMI后患者进行常规疲劳和抑郁筛查，以便为他们提供充分的支持和治疗，从而也改善他们的HRQoL。
