Cammarota Anna Lisa, Falco Antonia, Basile Anna, Molino Carlo, Chetta Massimiliano, D'Angelo Gianni, Marzullo Liberato, De Marco Margot, Turco Maria Caterina, Rosati Alessandra
Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
General Surgery Unit, A.O.R.N. Cardarelli, 80131 Naples, Italy.
Cancers (Basel). 2023 Oct 1;15(19):4825. doi: 10.3390/cancers15194825.
Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.
胰腺导管腺癌（PDAC）是一种预后不良的毁灭性疾病，需要更详细地了解其生物学特性以促进有效治疗方法的开发。针对细胞增殖及其相关机制的治疗效果不尽人意，这表明研究重点应转向炎症性肿瘤微环境（TME）。在此，我们讨论癌症分泌蛋白在复杂的TME肿瘤-基质相互作用中的作用，为开发创新、更安全、更有效的治疗策略提供可成药分子靶点的线索。
