• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

NT-proBNP——伴有心血管危险因素和SARS-CoV-2感染的孕妇可能的预后标志物。

NT-proBNP-Possible Prognostic Marker in Pregnant Patients with Associated Cardiovascular Risk Factors and SARS-CoV-2 Infection.

作者信息

Marta Carmen-Ioana, Maghiari Anca Laura, Bernad Elena, Stelea Lavinia, Bernad Brenda, Boscu Lioara, Neamtu Radu, Gluhovschi Adrian, Diaconu Mircea, Dumitru Catalin, Sorop Bogdan, Babes Katalin

机构信息

Faculty of Medicine and Pharmacy of Oradea, University of Oradea, 410087 Oradea, Romania.

Clinic of Obstetrics and Gynecology, "Pius Brinzeu" County Clinical Emergency Hospital, 300723 Timisoara, Romania.

出版信息

Diagnostics (Basel). 2023 Sep 23;13(19):3032. doi: 10.3390/diagnostics13193032.

DOI:10.3390/diagnostics13193032
PMID:37835775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10572047/
Abstract

BACKGROUND

N-terminal pro brain-type natriuretic peptide (NT-proBNP) is a practical biomarker in the clinical pathologies where the ventricle is under stress and particularly stretched in the general population. The study aims to compare the value of NT-proBNP and its importance in the prognosis and severity of the cases involving pregnant patients with SARS-CoV-2 infection and cardiovascular risk factors to those of low-risk pregnant patients, mainly by analysing their symptoms, administered medication, days of hospitalization and severity of the viral disease.

METHODS

The study included a total of eighty-three pregnant patients who underwent natural birth or caesarean section at out hospital. NT-proBNP levels were analyzed at hospital admission as a potential cardiovascular marker. A comparative analysis was performed between pregnant patients with cardiovascular risk factors and pregnant patients without cardiovascular risk factors regarding NT-proBNP values.

RESULTS

Pregnant patients with SARS-CoV-2 infection and cardiovascular risk factors had higher values of NT-proBNP in comparison to pregnant patients without cardiovascular risk factors.

CONCLUSIONS

NT-proBNP testing in pregnant patients with SARS-CoV-2 infection can be a relatively important marker to be taken into consideration when it comes to the management, treatment and outcome of the cases, especially when it comes to women with associated cardiovascular risk factors.

摘要

背景

N端前脑钠肽（NT-proBNP）是一种实用的生物标志物，适用于心室承受压力尤其是在普通人群中出现心室扩张的临床病理情况。本研究旨在比较NT-proBNP的价值及其在感染SARS-CoV-2且有心血管危险因素的孕妇病例与低风险孕妇病例的预后和严重程度方面的重要性，主要通过分析她们的症状、用药情况、住院天数和病毒性疾病的严重程度来进行比较。

方法

本研究共纳入了83例在我院自然分娩或剖宫产的孕妇。入院时分析NT-proBNP水平，将其作为潜在的心血管标志物。对有心血管危险因素的孕妇和无心血管危险因素的孕妇的NT-proBNP值进行了对比分析。

结果

与无心血管危险因素的孕妇相比，感染SARS-CoV-2且有心血管危险因素的孕妇NT-proBNP值更高。

结论

对于感染SARS-CoV-2的孕妇，NT-proBNP检测在病例的管理、治疗和预后方面可能是一个需要考虑的相对重要的标志物，尤其是对于伴有心血管危险因素的女性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da04/10572047/ec4e690a7a63/diagnostics-13-03032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da04/10572047/ec4e690a7a63/diagnostics-13-03032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da04/10572047/ec4e690a7a63/diagnostics-13-03032-g001.jpg

相似文献

1
NT-proBNP-Possible Prognostic Marker in Pregnant Patients with Associated Cardiovascular Risk Factors and SARS-CoV-2 Infection.NT-proBNP——伴有心血管危险因素和SARS-CoV-2感染的孕妇可能的预后标志物。
Diagnostics (Basel). 2023 Sep 23;13(19):3032. doi: 10.3390/diagnostics13193032.
2
Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns.感染和未感染SARS-CoV-2的孕妇NT-proBNP水平的变化：对新生儿的影响
Biomedicines. 2023 Nov 2;11(11):2964. doi: 10.3390/biomedicines11112964.
3
A Comparative Analysis of NT-proBNP Levels in Pregnant Women and the Impact of SARS-CoV-2 Infection: Influence on Birth Outcome.孕妇NT-proBNP水平的比较分析以及SARS-CoV-2感染的影响：对分娩结局的影响
Diseases. 2023 Dec 30;12(1):10. doi: 10.3390/diseases12010010.
4
Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease.氨基末端 B 型利钠肽原、肌钙蛋白 T 和生长分化因子 15 在成人先天性心脏病中的预后价值。
Circulation. 2017 Jan 17;135(3):264-279. doi: 10.1161/CIRCULATIONAHA.116.023255. Epub 2016 Nov 3.
5
The Interplay between Fasting Glucose, Echocardiography, and Biomarkers: Pathophysiological Considerations and Prognostic Implications.空腹血糖、超声心动图与生物标志物之间的相互作用：病理生理考量及预后意义
Dan Med J. 2017 Sep;64(9).
6
N-terminal pro brain natriuretic peptide in the management of patients in the medical emergency department (PROMPT): correlation with disease severity, utilization of hospital resources, and prognosis in a large, prospective, randomized multicentre trial.N 端脑利钠肽前体在急诊医学科患者管理中的应用（PROMPT）：与疾病严重程度、医院资源利用及预后的相关性——一项大型前瞻性随机多中心试验
Eur J Heart Fail. 2012 Mar;14(3):259-67. doi: 10.1093/eurjhf/hfr171. Epub 2012 Jan 20.
7
N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID-19 in a Nationwide Hospitalized Cohort.N 端脑利钠肽前体作为全国住院患者队列中 COVID-19 严重程度和结局的生物标志物。
J Am Heart Assoc. 2021 Dec 21;10(24):e022913. doi: 10.1161/JAHA.121.022913. Epub 2021 Dec 10.
8
NT-proBNP: When is it useful in Obstetric Medicine?N末端B型利钠肽原：它在产科医学中何时有用？
Obstet Med. 2018 Mar;11(1):3-5. doi: 10.1177/1753495X17736717. Epub 2017 Nov 22.
9
Prognostic value of N-terminal-pro-brain natriuretic peptide measurements in patients with acute coronary syndromes.N 末端脑钠肽前体测定在急性冠脉综合征患者中的预后价值。
Cardiovasc J S Afr. 2006 Mar-Apr;17(2):60-6.
10
Prognostic value of NT-proBNP in patients with severe COVID-19.NT-proBNP 对重症 COVID-19 患者的预后价值。
Respir Res. 2020 Apr 15;21(1):83. doi: 10.1186/s12931-020-01352-w.

本文引用的文献

1
Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population.美国普通人群中孕妇NT-proBNP升高的患病率及其相关因素
JACC Adv. 2023 Mar;2(2). doi: 10.1016/j.jacadv.2023.100265. Epub 2023 Mar 8.
2
Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.奥密克戎变异株流行期间的妊娠结局和疫苗效力：INTERCOVID-2022 多国观察性研究。
Lancet. 2023 Feb 11;401(10375):447-457. doi: 10.1016/S0140-6736(22)02467-9. Epub 2023 Jan 17.
3
Hypertensive disorders of pregnancy and long-term cardiovascular health: FIGO Best Practice Advice.
妊娠高血压疾病与长期心血管健康：FIGO 最佳实践建议。
Int J Gynaecol Obstet. 2023 Jan;160 Suppl 1:22-34. doi: 10.1002/ijgo.14540.
4
Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week.不适当窦性心动过速：病因、病理生理学和管理：JACC 每周综述专题。
J Am Coll Cardiol. 2022 Jun 21;79(24):2450-2462. doi: 10.1016/j.jacc.2022.04.019.
5
Association of N-Terminal Pro-Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension.早孕期 N 端脑利钠肽前体浓度与妊娠高血压疾病及未来高血压的发生有关。
JAMA Cardiol. 2022 Mar 1;7(3):268-276. doi: 10.1001/jamacardio.2021.5617.
6
Diabetes mellitus, maternal adiposity, and insulin-dependent gestational diabetes are associated with COVID-19 in pregnancy: the INTERCOVID study.糖尿病、母体肥胖和胰岛素依赖型妊娠期糖尿病与妊娠期 COVID-19 相关：INTERCOVID 研究。
Am J Obstet Gynecol. 2022 Jul;227(1):74.e1-74.e16. doi: 10.1016/j.ajog.2021.12.032. Epub 2021 Dec 20.
7
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.2021年欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南。
Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368.
8
Admission NT-proBNP and outcomes in patients without history of heart failure hospitalized with COVID-19.因 COVID-19 住院且无心力衰竭史的患者中 NT-proBNP 入院水平与结局。
ESC Heart Fail. 2021 Oct;8(5):4278-4287. doi: 10.1002/ehf2.13548. Epub 2021 Aug 4.
9
Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study.子痫前期与 COVID-19：INTERCOVID 前瞻性纵向研究结果。
Am J Obstet Gynecol. 2021 Sep;225(3):289.e1-289.e17. doi: 10.1016/j.ajog.2021.05.014. Epub 2021 Jun 26.
10
Characterization of NT-proBNP in a large cohort of COVID-19 patients.对大量 COVID-19 患者的 NT-proBNP 进行特征描述。
Eur J Heart Fail. 2021 Mar;23(3):456-464. doi: 10.1002/ejhf.2095. Epub 2021 Feb 1.