Buroker T, Padilla F, Groppe C, Guy G, Quagliana J, McCracken J, Vaitkevicius V K, Hoogstraten B, Heilbrun L
Cancer. 1979 Jul;44(1):48-51. doi: 10.1002/1097-0142(197907)44:1<48::aid-cncr2820440109>3.0.co;2-c.
Eighty-four previously untreated patients with metastatic adenocarcinoma of the large intestine received intravenous ftorafur at a dosage of 2.25 g/m2/day for 5 consecutive days. Courses were repeated every three weeks. Regressions were noted in 9 of 84 treated patients (11%). Median survival for all patients was 32 weeks. Responders survived only 5 weeks longer than nonresponders; 36 vs. 31 weeks. Central nervous system toxicity was a limiting factor occurring in one-third of patients. Ftorafur in a daily X5 schedule appears not to make a significant contribution to the management of disseminated colorectal cancer.
84例先前未经治疗的大肠转移性腺癌患者接受静脉注射喃氟啶，剂量为2.25 g/m²/天，连续5天。每三周重复一个疗程。84例接受治疗的患者中有9例（11%）出现肿瘤消退。所有患者的中位生存期为32周。有反应者比无反应者仅多存活5周；分别为36周和31周。中枢神经系统毒性是一个限制因素，三分之一的患者出现该毒性。每日一次共5天的喃氟啶给药方案似乎对播散性结直肠癌的治疗没有显著贡献。
