Spanish Academy of Nutrition and Dietetics, 31006 Pamplona, Spain.
Nutrition and Digestive Working Group, Spanish Society of Clinical, Family, and Community Pharmacy (SEFAC), 28045 Madrid, Spain.
Nutrients. 2023 Oct 6;15(19):4274. doi: 10.3390/nu15194274.
Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multilevel "omics" compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between the SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and scientific evidence supports the anticancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of the SEAD's bioactive compounds against cancer.
科学证据越来越多地支持饮食与健康之间的紧密联系，承认均衡的饮食对于预防肥胖、糖尿病、心血管问题和某些类型的癌症等慢性疾病起着至关重要的作用。这一观点为开发精准饮食打开了大门，特别是针对有患癌风险的个体量身定制的饮食。它涵盖了广泛的研究领域，涉及对具有多层次“组学”组成的大量化合物的研究，包括基因组学、转录组学、蛋白质组学、表观基因组学、miRNomics 和代谢组学。我们从化学和药理学的角度回顾了南欧大西洋饮食（SEAD）的组成部分。参考的信息来源，辅以蛋白质数据库中的晶体学数据，在 SEAD 与其抗癌特性之间建立了直接联系。收集的数据强烈表明，SEAD 提供了一种非常健康的饮食模式，特别是由于其食物中存在有益的生物分子。橄榄油和辣椒粉的加入为这种饮食提供了许多健康益处，科学证据支持从芸苔属蔬菜中提取生物分子的膳食补充剂具有抗癌特性。然而，在这一领域还需要进一步的研究，以更深入地了解 SEAD 的生物活性化合物对癌症的潜在益处。
