The Leviev Cardiothoracic & Vascular Center, Sheba Medical Center, Ramat Gan 5262504, Israel.
The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Nutrients. 2023 Oct 9;15(19):4299. doi: 10.3390/nu15194299.
Low serum magnesium (sMg) is associated with cardiovascular risk factors and atherosclerotic disease.
To evaluate the association between sMg levels on admission and clinical outcomes in hospitalized non-ST-elevation myocardial infarction (NSTEMI) patients.
A retrospective analysis of all patients admitted to a single tertiary center with a primary diagnosis of NSTEMI. Patients with advanced chronic kidney disease were excluded. Clinical data were collected and compared between lower sMg quartile patients (Q1; sMg < 1.9 mg/dL) and all other patients (Q2-Q4; sMg ≥ 1.9 mg/dL).
The study cohort included 4552 patients (70% male, median age 69 [IQR 59-79]) who were followed for a median of 4.4 (IQR 2.4-6.6) years. The median sMg level in the low sMg group was 1.7 (1.6-1.8) and 2.0 (2.0-2.2) mg/dL in the normal/high sMg group. The low sMg group was older (mean of 72 vs. 67 years), less likely to be male (64% vs. 72%), and had higher rates of comorbidities, including diabetes, hypertension, and atrial fibrillation (59% vs. 29%, 92% vs. 85%, and 6% vs. 5%; < 0.05 for all). Kaplan-Meier survival analysis demonstrated significantly higher cumulative death probability at 4 years in the low sMg group (34% vs. 22%; log rank <0.001). In a multivariable analysis model adjusted for sex, significant comorbidities, coronary interventions during the hospitalization, and renal function, the low sMg group exhibited an independent 24% increased risk of death during follow up (95% CI 1.11-1.39; < 0.001).
Low sMg is independently associated with higher risk of long-term mortality among patients recovering from an NSTEMI event.
血清镁（sMg）水平较低与心血管危险因素和动脉粥样硬化性疾病相关。
评估入院时 sMg 水平与住院非 ST 段抬高型心肌梗死（NSTEMI）患者临床结局的相关性。
对单一三级中心因 NSTEMI 入院的所有患者进行回顾性分析。排除晚期慢性肾脏病患者。收集并比较 sMg 四分位较低组（Q1；sMg＜1.9mg/dL）和所有其他患者（Q2-Q4；sMg≥1.9mg/dL）的临床数据。
研究队列包括 4552 例患者（70%为男性，中位年龄 69[IQR 59-79]岁），中位随访时间为 4.4（IQR 2.4-6.6）年。低 sMg 组的中位 sMg 水平为 1.7（1.6-1.8）mg/dL，正常/高 sMg 组为 2.0（2.0-2.2）mg/dL。低 sMg 组年龄较大（平均 72 岁 vs. 67 岁），男性比例较低（64% vs. 72%），合并症发生率较高，包括糖尿病、高血压和心房颤动（59% vs. 29%、92% vs. 85%和 6% vs. 5%；所有 P 值均＜0.05）。Kaplan-Meier 生存分析显示，低 sMg 组 4 年时的累积死亡率明显较高（34% vs. 22%；log rank＜0.001）。在校正性别、显著合并症、住院期间的冠状动脉介入治疗和肾功能后，多变量分析模型显示低 sMg 组在随访期间死亡风险增加 24%（95%CI 1.11-1.39；P＜0.001）。
在恢复 NSTEMI 事件的患者中，低 sMg 与长期死亡率升高独立相关。
