Geriatric Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Geriatr Gerontol Int. 2024 Mar;24 Suppl 1(Suppl 1):44-48. doi: 10.1111/ggi.14684. Epub 2023 Oct 13.
Aging shows biologically complex features with high individual variability, which reflects the exposure to several stimuli and the adaptation to them. Among them, metabolic changes are well observed as consequences or possible causes of aging. Calorie restriction extends organismal life span in experimental models. Several metabolites; for example, resveratrol or nicotinamide mononucleotide, are reported to mimic calorie restriction effects in vivo. Metabolomic research would be useful to evaluate metabolites as biomarkers in aging-relevant events and to identify metabolic regulation of aging. We recently developed the metabolomic approach for whole blood analysis, which functions as strong tool for this purpose. We review the update findings in aging-relevant metabolites detected by this method. Geriatr Gerontol Int 2024; 24: 44-48.
衰老是一种具有高度个体差异的复杂生物学特征，反映了机体对多种刺激的暴露和适应。其中，代谢变化是衰老的后果或可能原因，这一点得到了很好的观察。在实验模型中，热量限制可以延长生物体的寿命。一些代谢物，如白藜芦醇或烟酰胺单核苷酸，被报道可以在体内模拟热量限制的效果。代谢组学研究将有助于评估代谢物作为与衰老相关事件的生物标志物，并确定衰老的代谢调控。我们最近开发了用于全血分析的代谢组学方法，该方法是实现这一目标的有力工具。我们综述了该方法检测到的与衰老相关的代谢物的最新发现。老年医学与老年病学杂志 2024; 24: 44-48.
