Thu Pyae Pyae, Tauro Joseph, Russell Heather, Kirpalani Aditi
Gold Coast University Hospital, Gold Coast, Queensland, Australia.
J Paediatr Child Health. 2023 Dec;59(12):1289-1295. doi: 10.1111/jpc.16504. Epub 2023 Oct 13.
The aim of the study was to look at the incidence and trend of retinopathy of prematurity (ROP) between 2017 and 2021 in a tertiary neonatal intensive care unit (NICU) in Australia and to compare potential modifiable risk factors of ROP between preterm infants who required treatment for ROP and who did not need treatment.
This retrospective study used the data of newborn infants who were <31 weeks gestational age (GA) or birth weight (BW) of <1250 g born between 2017 and 2021 at a tertiary NICU in Australia (n = 261). Univariate analysis using t test for continuous data, Fischer exact test for categorical data and multiple logistic regression analysis were undertaken to identify any significant differences between two groups.
A total number of 261 infants were studied. 55.9% of infants developed any type of ROP (146 infants out of 261 infants), type 1 ROP was 5.4% (14 out of 261) and aggressive ROP (AROP) was 3% (8 out of 261). Out of 146 infants who were diagnosed with ROP, 22 (15%) of them required treatment. Mean GA for those who underwent ROP treatment was 25.6 (±1.47) weeks and for those who did not require treatment was 27.6 (±1.95) weeks. The mean BWs for those who needed treatment was 764 (±189.32) g and for those who did not need treatment was 1039 (±306.06) g. The mean duration of invasive ventilation for infants with ROP requiring treatment and those who did not require treatment were 23.95 (±22.41) days and 9.89 (±17.2) days. The total duration of oxygen requirement was 235.54 (±160.5) days and 121.11 (±117.34) days for those who needed treatment and those who did not need treatment respectively. Among infants who required treatment for ROP, 68.18% required blood transfusion whereas among those who did not need treatment, 24.19% required blood transfusion.
Lower GA, lower BW, longer duration of invasive ventilation, longer total duration of oxygen requirement and blood transfusion in first 2 weeks of life were significant in preterm infants who required treatment for ROP compared with those who did not.
本研究旨在观察2017年至2021年澳大利亚一家三级新生儿重症监护病房（NICU）中早产儿视网膜病变（ROP）的发病率及趋势，并比较需要接受ROP治疗和无需治疗的早产儿之间潜在的可改变的ROP危险因素。
这项回顾性研究使用了2017年至2021年在澳大利亚一家三级NICU出生的胎龄小于31周（GA）或出生体重（BW）小于1250克的新生儿的数据（n = 261）。采用t检验对连续数据进行单因素分析，采用费舍尔精确检验对分类数据进行分析，并进行多因素逻辑回归分析，以确定两组之间的任何显著差异。
共研究了261名婴儿。55.9%的婴儿发生了任何类型的ROP（261名婴儿中有146名），1型ROP为5.4%（261名中有14名），侵袭性ROP（AROP）为3%（261名中有8名）。在146名被诊断为ROP的婴儿中，22名（15%）需要治疗。接受ROP治疗的婴儿的平均GA为25.6（±1.47）周，未接受治疗的婴儿的平均GA为27.6（±1.95）周。需要治疗的婴儿的平均BW为764（±189.32）克，不需要治疗的婴儿的平均BW为1039（±306.06）克。需要治疗和不需要治疗的ROP婴儿的有创通气平均持续时间分别为23.95（±22.41）天和9.89（±17.2）天。需要治疗和不需要治疗的婴儿的总吸氧时间分别为235.54（±160.5）天和121.11（±117.34）天。在需要接受ROP治疗的婴儿中，68.18%需要输血，而在不需要治疗的婴儿中，24.19%需要输血。
与无需治疗的早产儿相比，需要接受ROP治疗的早产儿胎龄更小、出生体重更低、有创通气持续时间更长、总吸氧时间更长以及出生后前2周内输血，这些因素具有显著意义。
