Kentish J C, Allen D G
J Mol Cell Cardiol. 1986 Sep;18(9):879-84. doi: 10.1016/s0022-2828(86)80001-3.
We believe that the weight of present evidence suggests that acute contractile failure in hypoxic or ischaemic cardiac muscle is accompanied by a fall in A but this fall is not the direct cause of the reduced force production. The main established causes of acute contractile failure are the effects of intracellular pH and of Pi accumulation on the contractile proteins and, at a later stage, failure of calcium release. It is worth stressing the role of Pi accumulation both because the effects of Pi have only been recognised relatively recently and because it has a large depressant effect. Pi accumulation is the best candidate to explain the rapid fall of force which occurs during hypoxia and ischaemia when ATP levels are unchanged and before pH changes are substantial.
我们认为，目前的证据表明，缺氧或缺血心肌的急性收缩功能衰竭伴随着A的下降，但这种下降并非力产生减少的直接原因。急性收缩功能衰竭的主要既定原因是细胞内pH值和无机磷酸盐（Pi）积累对收缩蛋白的影响，以及在后期钙释放功能衰竭。值得强调Pi积累的作用，这是因为Pi的影响直到最近才被认识到，而且它具有很大的抑制作用。Pi积累是解释在缺氧和缺血期间ATP水平未变且pH值变化不大之前力迅速下降的最佳候选因素。
