Poole-Wilson P A
Lancet. 1975 Dec 27;2(7948):1285-7. doi: 10.1016/s0140-6736(75)90616-9.
There is no satisfactory explanation for the early and rapid decline of cardiac muscle function in ischaemia. Reduction of the energy source for contraction, A.T.P., is insufficient in magnitude and too slow in onset to be the prime cause. It is proposed that a large part of the loss of function is directly attributable to an immediate fall of intracellular pH and results from the accumulation of carbon dioxide and lactic acid; the intracellular acidosis reduces myocardial function by inhibition of that part of the calcium-ion influx associated with contraction.
对于缺血时心肌功能早期快速衰退，目前尚无令人满意的解释。收缩能量来源三磷酸腺苷（ATP）的减少，在程度上并不充分，且发生过于缓慢，不足以成为主要原因。有人提出，功能丧失的很大一部分直接归因于细胞内pH值的即刻下降，这是由二氧化碳和乳酸的积聚所致；细胞内酸中毒通过抑制与收缩相关的那部分钙离子内流来降低心肌功能。
