Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Curr Med Sci. 2023 Dec;43(6):1066-1074. doi: 10.1007/s11596-023-2797-3. Epub 2023 Oct 14.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that suddenly emerged at the end of December 2019 and caused coronavirus disease 2019 (COVID-19) continues to afflict humanity, not only seriously affecting healthcare systems but also leading to global social and economic imbalances. As of August 2022, there were approximately 580 million confirmed cases of COVID-19 and approximately 6.4 million confirmed deaths due to this disease. The data are sufficient to highlight the seriousness of SARS-CoV-2 infection. Although most patients with COVID-19 present primarily with respiratory symptoms, an increasing number of extrapulmonary systemic symptoms and manifestations have been associated with COVID-19. Since the outbreak of COVID-19, much has been learned about the disease and its causative agent. Therefore, great effort has been aimed at developing treatments and drug interventions to treat and reduce the incidence of COVID-19. In this narrative review, we provide a brief overview of the epidemiology, mechanisms, clinical manifestations, diagnosis, and therapeutics of COVID-19.
新型严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）于 2019 年 12 月底突然出现，引发 2019 年冠状病毒病（COVID-19），继续困扰着人类，不仅严重影响医疗保健系统，还导致全球社会和经济失衡。截至 2022 年 8 月，全球约有 5.8 亿例 COVID-19 确诊病例，约有 640 万人死于 COVID-19。这些数据足以突出 SARS-CoV-2 感染的严重性。虽然大多数 COVID-19 患者主要表现为呼吸道症状，但越来越多的肺外全身症状和表现与 COVID-19 相关。自 COVID-19 爆发以来，人们对该疾病及其病原体有了更多的了解。因此，人们致力于开发治疗方法和药物干预措施来治疗和降低 COVID-19 的发病率。在这篇叙述性综述中，我们简要概述了 COVID-19 的流行病学、发病机制、临床表现、诊断和治疗方法。
