Miyauchi A, Onishi T, Matsuzuka F, Hirai K, Kuma K, Takai S, Nakamoto K, Nakamura K, Nanjo S, Maeda M
Gan No Rinsho. 1986 Oct;32(12):1519-24.
Fifteen patients operated on for medullary thyroid carcinoma with elevated postoperative serum calcitonin (CT) levels underwent serial measurements of serum CT and carcinoembryonic antigen (CEA) levels. Both CT and CEA levels showed an exponential increase in 12 patients and a slight decrease in three. CEA levels manifested less fluctuation than CT levels. The doubling time of these tumor marker levels calculated from the regression line in each patient showed a strong correlation with three-year survival, recurrence within five years, and the time interval between surgery and recurrence of the tumor, allowing quantitative prediction of the prognosis. However, the doubling time of CEA was longer than that of CT in most patients.
15例接受手术治疗的甲状腺髓样癌患者术后血清降钙素（CT）水平升高，对其进行了血清CT和癌胚抗原（CEA）水平的系列测量。CT和CEA水平在12例患者中呈指数上升，3例呈轻微下降。CEA水平的波动小于CT水平。根据每位患者的回归线计算出的这些肿瘤标志物水平的倍增时间与三年生存率、五年内复发情况以及手术与肿瘤复发之间的时间间隔密切相关，从而能够对预后进行定量预测。然而，在大多数患者中，CEA的倍增时间长于CT的倍增时间。
