澳大利亚初级保健中强化生活方式干预对早期 2 型糖尿病缓解的效果：DiRECT-Aus 研究。
Intensive Lifestyle Intervention for Remission of Early Type 2 Diabetes in Primary Care in Australia: DiRECT-Aus.
机构信息
Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Charles Perkins Centre, University of Sydney, Sydney, Australia.
出版信息
Diabetes Care. 2024 Jan 1;47(1):66-70. doi: 10.2337/dc23-0781.
OBJECTIVE
We aimed to assess whether remission of type 2 diabetes (T2D) could be achieved with a low-energy total diet replacement (TDR) in an Australian primary care setting.
RESEARCH DESIGN AND METHODS
Individuals aged 20-65 years with T2D duration up to 6 years, BMI >27.0 kg/m2, and not treated with insulin were prescribed a 13-week low-energy TDR (Optifast; Nestlé Health Science) followed by 8-week structured food reintroduction and 31-week supported weight maintenance. The primary outcome was T2D remission at 12 months.
RESULTS
A total of 155 participants comprised the intention-to-treat population. At 12 months, T2D remission was achieved in 86 (56%) participants, with a mean adjusted weight loss of 8.1% (95% CI 7.2-9.1). Two serious adverse events requiring hospitalization related to the study intervention were reported.
CONCLUSIONS
At 12 months T2D remission was achieved for one in two Australian adults in a primary care setting.
目的
我们旨在评估在澳大利亚初级保健环境中，低能量总膳食替代（TDR）是否可实现 2 型糖尿病（T2D）的缓解。
研究设计和方法
患有 T2D 持续时间长达 6 年、BMI>27.0 kg/m2 且未接受胰岛素治疗的 20-65 岁个体，被规定进行为期 13 周的低能量 TDR（Optifast；雀巢健康科学公司），随后进行 8 周的结构化食物重新引入和 31 周的支持性体重维持。主要结局是 12 个月时的 T2D 缓解。
结果
共有 155 名参与者构成意向治疗人群。在 12 个月时，86 名（56%）参与者达到 T2D 缓解，平均调整后体重减轻 8.1%（95%CI 7.2-9.1）。报告了两例与研究干预相关的需住院治疗的严重不良事件。
结论
在 12 个月时，在初级保健环境中，有二分之一的澳大利亚成年人实现了 T2D 缓解。
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