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Restarting anticoagulant therapy after intracranial hemorrhage in patients with atrial fibrillation: A nationwide retrospective cohort study.心房颤动患者颅内出血后重启抗凝治疗：一项全国性回顾性队列研究。
Int J Cardiol Heart Vasc. 2022 Apr 26;40:101037. doi: 10.1016/j.ijcha.2022.101037. eCollection 2022 Jun.
2
2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association.2022年自发性脑出血患者管理指南：美国心脏协会/美国中风协会指南
Stroke. 2022 Jul;53(7):e282-e361. doi: 10.1161/STR.0000000000000407. Epub 2022 May 17.
3
When is it safe to resume anticoagulation in traumatic brain injury?颅脑损伤后何时可以安全恢复抗凝治疗？
Curr Opin Anaesthesiol. 2022 Apr 1;35(2):166-171. doi: 10.1097/ACO.0000000000001117.
4
Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy.依达赛珠单抗在颅内出血中的止血效果和抗 FXa（因子 Xa）作用逆转：ANNEXA-4 子研究。
Stroke. 2021 Jun;52(6):2096-2105. doi: 10.1161/STROKEAHA.120.030565. Epub 2021 May 10.
5
Timing of Restarting Anticoagulation and Antiplatelet Therapies After Traumatic Subdural Hematoma-A Single Institution Experience.创伤性硬脑膜下血肿后重启抗凝和抗血小板治疗的时机：单中心经验。
World Neurosurg. 2021 Jun;150:e203-e208. doi: 10.1016/j.wneu.2021.02.135. Epub 2021 Mar 5.
6
Anticoagulation therapy in patients with traumatic brain injury: An Eastern Association for the Surgery of Trauma multicenter prospective study.创伤性脑损伤患者的抗凝治疗：东部创伤外科学会多中心前瞻性研究。
Surgery. 2021 Feb;169(2):470-476. doi: 10.1016/j.surg.2020.07.040. Epub 2020 Sep 12.
7
Updated guidelines to reduce venous thromboembolism in trauma patients: A Western Trauma Association critical decisions algorithm.降低创伤患者静脉血栓栓塞的更新指南：西部创伤协会关键决策算法
J Trauma Acute Care Surg. 2020 Nov;89(5):971-981. doi: 10.1097/TA.0000000000002830.
8
Therapeutic anticoagulation in patients with traumatic brain injuries and pulmonary emboli.创伤性脑损伤合并肺栓塞患者的治疗性抗凝。
J Trauma Acute Care Surg. 2020 Sep;89(3):529-535. doi: 10.1097/TA.0000000000002805.
9
Antithrombotics in intracerebral hemorrhage in the era of novel agents and antidotes: A review.新型药物和解毒剂时代的脑出血中的抗血栓药物：综述。
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Early Administration of Desmopressin and Platelet Transfusion for Reducing Hematoma Expansion in Patients With Acute Antiplatelet Therapy Associated Intracerebral Hemorrhage.早期给予去氨加压素和血小板输注治疗急性抗血小板治疗相关脑出血患者血肿扩大。
Crit Care Med. 2020 Jul;48(7):1009-1017. doi: 10.1097/CCM.0000000000004348.

创伤性脑损伤后抗凝和抗血小板药物的恢复时机

Anticoagulation and Antiplatelet Agent Resumption Timing following Traumatic Brain Injury.

作者信息

Jung In-Ho, Yun Jung-Ho, Kim Sung Jin, Chung Jaewoo, Lee Sang Koo

机构信息

Department of Neurosurgery, Dankook University College of Medicine, Cheonan, Korea.

出版信息

Korean J Neurotrauma. 2023 Sep 12;19(3):298-306. doi: 10.13004/kjnt.2023.19.e42. eCollection 2023 Sep.

DOI:10.13004/kjnt.2023.19.e42
PMID:37840609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10567523/
Abstract

Traumatic brain injury (TBI) is a major global health concern. Due to the increase in TBI incidence and the aging population, an increasing number of patients with TBI are taking antithrombotic agents for their underlying disease. When TBI occurs in patients with these diseases, there is a conflict between the disease, which requires an antithrombotic effect, and the neurosurgeon, who must minimize intracranial hemorrhage. Nevertheless, there are no clear guidelines for the reversal or resumption of antithrombotic agents when TBI occurs in patients taking antithrombotic agents. In this review article, we intend to classify antithrombotic agents and provide information on them. We also share previous studies on the reversal and resumption of antithrombotic agents in patients with TBI to help neurosurgeons in this dilemma.

摘要

创伤性脑损伤（TBI）是一个重大的全球健康问题。由于TBI发病率的上升和人口老龄化，越来越多的TBI患者因基础疾病而服用抗血栓药物。当这些疾病患者发生TBI时，需要抗血栓作用的疾病与必须尽量减少颅内出血的神经外科医生之间存在冲突。然而，对于正在服用抗血栓药物的患者发生TBI时抗血栓药物的逆转或恢复，尚无明确的指南。在这篇综述文章中，我们打算对抗血栓药物进行分类并提供相关信息。我们还分享了之前关于TBI患者抗血栓药物逆转和恢复的研究，以帮助处于这一困境中的神经外科医生。